DNA methylation in mammalian development and disease
ZD Smith, S Hetzel, A Meissner - Nature Reviews Genetics, 2024 - nature.com
The DNA methylation field has matured from a phase of discovery and genomic
characterization to one seeking deeper functional understanding of how this modification …
characterization to one seeking deeper functional understanding of how this modification …
Clonal hematopoiesis and hematological malignancy
WG Dunn, MA McLoughlin, GS Vassiliou - The Journal of Clinical …, 2024 - jci.org
Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …
driven by somatic mutations in leukemia-associated genes, is a common phenomenon that …
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
M Cortés-López, P Chamely, AG Hawkins, RF Stanley… - Cell Stem Cell, 2023 - cell.com
RNA splicing factors are recurrently mutated in clonal blood disorders, but the impact of
dysregulated splicing in hematopoiesis remains unclear. To overcome technical limitations …
dysregulated splicing in hematopoiesis remains unclear. To overcome technical limitations …
Selective advantage of mutant stem cells in clonal hematopoiesis occurs by attenuating the deleterious effects of inflammation and aging
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSC) acquire mutations
in genes, including DNMT3A and TET2, conferring a competitive advantage through a …
in genes, including DNMT3A and TET2, conferring a competitive advantage through a …
Epigenetic Mechanisms in Hematologic Aging and Premalignant Conditions
Hematopoietic stem cells (HSCs) are essential for maintaining overall health by
continuously generating blood cells throughout an individual's lifespan. However, as …
continuously generating blood cells throughout an individual's lifespan. However, as …
Noncoding rules of survival: epigenetic regulation of normal and malignant hematopoiesis
LS Wallace, EA Obeng - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Hematopoiesis is an essential process for organismal development and homeostasis.
Epigenetic regulation of gene expression is critical for stem cell self-renewal and …
Epigenetic regulation of gene expression is critical for stem cell self-renewal and …
Zygotic Splicing Activation of the Transcriptome is a Crucial Aspect of Maternal‐to‐Zygotic Transition and Required for the Conversion from Totipotency to Pluripotency
During maternal‐to‐zygotic transition (MZT) in the embryo, mRNA undergoes complex post‐
transcriptional regulatory processes. However, it is unclear whether and how alternative …
transcriptional regulatory processes. However, it is unclear whether and how alternative …
GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases
Rheumatoid arthritis (RA) is characterized by joint synovitis and bone destruction, the
etiology of which remains to be explored. Many types of cells are involved in the progression …
etiology of which remains to be explored. Many types of cells are involved in the progression …
Splicing modulators impair DNA damage response and induce killing of cohesin-mutant MDS and AML
EC Wheeler, BJE Martin, WC Doyle, S Neaher… - Science translational …, 2024 - science.org
Splicing modulation is a promising treatment strategy pursued to date only in splicing factor-
mutant cancers; however, its therapeutic potential is poorly understood outside of this …
mutant cancers; however, its therapeutic potential is poorly understood outside of this …