Cancer in the broader sense refers to more than 277 different types of cancer disease.
Scientists have identified different stage of cancers, indicating that several gene mutations …

The logical (or logic) formalism is increasingly used to model regulatory and signaling
networks. Complementing these applications, several groups contributed various methods …

Flowers are the most complex structures of plants. Studies of Arabidopsis thaliana, which
has typical eudicot flowers, have been fundamental in advancing the structural and …

During flowering, primordia on the flanks of the shoot apical meristem are specified to form
flowers instead of leaves. Like many plants, Arabidopsis thaliana integrates environmental …

Purpose: We put forward a theoretical and dynamical approach for the semi-quantitative
analysis of CD4+ T cell differentiation, the process by which cells with different functions are …

Robust temporal and spatial patterns of cell types emerge in the course of normal
development in multicellular organisms. The onset of degenerative diseases may result from …

Cell state transition is at the core of biological processes in metazoan, which includes cell
differentiation, epithelial-to-mesenchymal transition (EMT) and cell reprogramming. In these …

The acrosome reaction (AR) is an exocytotic process essential for mammalian fertilization. It
involves diverse physiological changes (biochemical, biophysical, and morphological) that …

I revisit two theories of cell differentiation in multicellular organisms published a half-century
ago, Stuart Kauffman's global genome regulatory dynamics (GGRD) model and Roy Britten's …

Modeling stochasticity in gene regulatory networks is an important and complex problem in
molecular systems biology. To elucidate intrinsic noise, several modeling strategies such as …