Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

Simple Summary In this review, we present a detailed discussion of how the plasminogen-
activation system is utilized by tumor cells in their unrelenting attack on the tissues …

Hematopoiesis requires finely tuned regulation of gene expression at each stage of
development. The regulation of gene transcription involves not only individual transcription …

The etiology of autism spectrum disorder (ASD) remains unknown, but gene-environment
interactions, mediated through epigenetic mechanisms, are thought to be a key contributing …

Highlights•Ikaros family proteins are essential for lymphocyte development and
function.•Ikaros family deficiency in man leads to B cell deficiency, leukemia development …

In the last two decades, microglia have emerged as key contributors to disease progression
in many neurological disorders, not only by exerting their classical immunological functions …

Epigenetic regulation of chromatin plays a critical role in controlling stem cell function and
tumorigenesis. The histone lysine demethylase, KDM5B, which catalyzes the demethylation …

Lineage plasticity and stemness have been invoked as causes of therapy resistance in
cancer, because these flexible states allow cancer cells to dedifferentiate and alter their …

JARID1 proteins are histone demethylases that both regulate normal cell fates during
development and contribute to the epigenetic plasticity that underlies malignant …

CK2 is a ubiquitously expressed, constitutively active Ser/Thr protein kinase, which is
considered the most pleiotropic protein kinase in the human kinome. Such a pleiotropy …