Polydimethylsiloxane (PDMS) is the predominant material used for organ-on-a-chip devices
and microphysiological systems (MPSs) due to its ease-of-use, elasticity, optical …

Organ-on-A-chip (OoAC) devices are miniaturized, functional, in vitro constructs that aim to
recapitulate the in vivo physiology of an organ using different cell types and extracellular …

Current in-vitro 2D cultures and animal models present severe limitations in recapitulating
human physiopathology with striking discrepancies in estimating drug efficacy and side …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …

The desired organ in micro‐tissue models of organ‐on‐a‐chip (OoC) devices dictates the
optimum biomaterials, divided into natural and synthetic biomaterials. They can resemble …

The human brain and central nervous system (CNS) present unique challenges in drug
development for neurological diseases. One major obstacle is the blood–brain barrier …

With the emergence of the coronavirus disease 2019 (COVID-19), the world is experiencing
a profound human health crisis. The number of infections and deaths due to the severe …

There is an increasing need for better preclinical therapeutic development models suitable
for the human body. As a result, there has been a shift from traditional animal models to …

Recent advances in microfluidic technology and biomaterial science have augmented the
use of organ-on-chip (OoC) technology to closely mimic the human pathophysiology. Thus, it …

The identification of the role of tumor stroma—the tissue in the surroundings of cancer cells—
in cancer development, progression, and metastasis has revolutionized the fields of cancer …