Myogenesis is a complex and tightly regulated process, the end result of which is the
formation of a multinucleated myofibre with contractile capability. Typically, this process is …

Cytoplasmic phosphoinositides (PI) are critical regulators of the membrane–cytosol interface
that control a myriad of cellular functions despite their low abundance among phospholipids …

Background Skeletal muscle is the largest tissue in the body, and it affects motion,
metabolism and homeostasis. Skeletal muscle development comprises myoblast …

Maintenance of skeletal muscle function is critical for metabolic health and the disruption of
which exacerbates many chronic diseases such as obesity and diabetes. Skeletal muscle …

The adaptor protein APPL1 mediates the stimulatory effect of adiponectin on p38 mitogen-
activated protein kinase (MAPK) signaling, yet the underlying mechanism remains unclear …

Abstract Background Compound K (CK) is among the protopanaxadiol (PPD)-type
ginsenoside group, which produces multiple pharmacological effects. Herein, we examined …

Endosomal adaptor proteins are important regulators of signaling pathways underlying
many biological processes. These adaptors can integrate signals from multiple pathways via …

Ethnopharmacological relevance The roots of Achyranthes bidentata Blume are one of the
regularly used herbal drugs in Chinese medicine, and has been applied for strengthening …

Abstract Ginsenoside Rg3 (Rg3), amplified by iterative heating processing with fresh
ginseng, has a broad range of pharmacological activities and improves mitochondrial …

The upregulation of Wnt/β-catenin signaling occurs in virtually all types of kidney disease
and is associated with podocyte injury. However, the precise mechanisms involved in the …