Ischemic stroke, a major cause of mortality in the United States, often contributes to
disruption of the blood-brain barrier (BBB). The BBB along with its supportive cells …

Cells are covered by a surface layer of glycans that is referred to as the 'glycocalyx'. In this
review, we focus on the role of the glycocalyx in vascular diseases (atherosclerosis, stroke …

The endothelial glycocalyx has a profound influence at the vascular wall on the transmission
of shear stress, on the maintenance of a selective permeability barrier and a low hydraulic …

Patients with coronavirus disease 2019 (COVID-19) who are critically ill develop vascular
complications characterized by thrombosis of small, medium, and large vessels. Dysfunction …

Hyaluronan (HA) is a ubiquitous glycosaminoglycan of the extracellular matrix. It is present
in the endothelial glycocalyx covering the apical surface of endothelial cells. The endothelial …

Purpose In 2007 the two senior authors wrote a review on the structure and function of the
endothelial glycocalyx layer (Weinbaum in Annu Rev Biomed Eng 9: 121–167, 2007). Since …

The endothelial glycocalyx (EG), which covers the apical surface of the endothelial cells and
floats into the lumen of the vessels, is a key player in vascular integrity and cardiovascular …

In the vascular system, the endothelial surface layer (ESL) as the inner surface of blood
vessels affects mechanotransduction, vascular permeability, rheology, thrombogenesis, and …

The severe forms and worsened outcomes of COVID-19 (coronavirus disease 19) are
closely associated with hypertension and cardiovascular disease. Endothelial cells express …

Optimal vascular structure and function are essential for maintaining the physiological
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …