Genetic alterations affecting transforming growth factor–β (TGF-β) signaling are
exceptionally common in diseases and cancers of the gastrointestinal system. As a regulator …

Transforming growth factor-β (TGF-β) induces a pleiotropic pathway that is modulated by the
cellular context and its integration with other signaling pathways. In cancer, the pleiotropic …

Deciphering the shared genetic basis of distinct cancers has the potential to elucidate
carcinogenic mechanisms and inform broadly applicable risk assessment efforts. Here, we …

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …

Inhibitory Smads (I-Smads) have conserved carboxy-terminal MH2 domains but highly
divergent amino-terminal regions when compared with receptor-regulated Smads (R …

Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is
influenced by the local colonic environment and the patient's genetic background …

Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …

Between 2% to 5% of all colon cancers arise in the setting of well-defined inherited
syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated …

This review gives an account of recent advances in our knowledge of the molecular
mechanisms in colorectal cancer. Genetic changes in the germ line, combined with somatic …

This book is the third volume of the 4th Edition of the WHO series on histological and genetic
typing of human tumours. It is an authoritative, concise reference book providing an …