Cancer to bone: a fatal attraction
KN Weilbaecher, TA Guise, LK McCauley - Nature Reviews Cancer, 2011 - nature.com
When cancer metastasizes to bone, considerable pain and deregulated bone remodelling
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …
occurs, greatly diminishing the possibility of cure. Metastasizing tumour cells mobilize and …
Integrins and bone metastasis: integrating tumor cell and stromal cell interactions
JG Schneider, SR Amend, KN Weilbaecher - Bone, 2011 - Elsevier
Integrins on both tumor cells and the supporting host stromal cells in bone (osteoclasts, new
blood vessels, inflammatory cells, platelets and bone marrow stromal cells) play key roles in …
blood vessels, inflammatory cells, platelets and bone marrow stromal cells) play key roles in …
Lung megakaryocytes display distinct transcriptional and phenotypic properties
Megakaryocytes (MKs) are responsible for platelet biogenesis, which is believed to occur
canonically in adult bone marrow (BM) and in the fetal liver during development. However …
canonically in adult bone marrow (BM) and in the fetal liver during development. However …
High ploidy large cytoplasmic megakaryocytes are hematopoietic stem cells regulators and essential for platelet production
Megakaryocytes (MK) generate platelets. Recently, we and others, have reported MK also
regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic …
regulate hematopoietic stem cells (HSC). Here we show high ploidy large cytoplasmic …
[HTML][HTML] Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation
SY Heazlewood, RJ Neaves, B Williams, DN Haylock… - Stem cell …, 2013 - Elsevier
We report transplanted hemopoietic stem cells (HSC) preferentially lodge within two cells of
mature megakaryocytes (MM). With both populations comprising~ 0.2% of bone marrow …
mature megakaryocytes (MM). With both populations comprising~ 0.2% of bone marrow …
Bone marrow niche in immune thrombocytopenia: a focus on megakaryopoiesis
E Khodadi, AA Asnafi, S Shahrabi, M Shahjahani… - Annals of …, 2016 - Springer
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by increased
bleeding tendency and thrombocytopenia. In fact, the precise pathogenesis of this disease is …
bleeding tendency and thrombocytopenia. In fact, the precise pathogenesis of this disease is …
The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control
Megakaryocytes are rare cells found in the bone marrow, responsible for the everyday
production and release of millions of platelets into the bloodstream. Since the discovery and …
production and release of millions of platelets into the bloodstream. Since the discovery and …
Myosin heavy chain-derived peptide of Gadus morhua promotes proliferation and differentiation in osteoblasts and bone formation and maintains bone homeostasis in …
Gadus morhua is an important commercial fish rich in nutrients required for daily
metabolism. However, the regulation of G. morhua peptides (GMP) on osteoblast growth …
metabolism. However, the regulation of G. morhua peptides (GMP) on osteoblast growth …
Isolation and Characterization of Peptides from Mytilus edulis with Osteogenic Activity in Mouse MC3T3-E1 Preosteoblast Cells
Seafood provides a range of health benefits because of its high protein levels. In this study,
a novel peptide, YPRKDETGAERT, was identified from NHA-2 of Mytilus edulis by capillary …
a novel peptide, YPRKDETGAERT, was identified from NHA-2 of Mytilus edulis by capillary …
Identification and mechanism evaluation of a novel osteogenesis promoting peptide from Tubulin Alpha-1C chain in Crassostrea gigas
Marine shellfish provides a series of biofunctionality account of its high-protein level. In this
study, the osteogenic effect of a novel peptide, YRGDVVPK, from Crassostrea gigas protein …
study, the osteogenic effect of a novel peptide, YRGDVVPK, from Crassostrea gigas protein …