Inwardly rectifying K+ (Kir) channels allow K+ to move more easily into rather than out of the
cell. They have diverse physiological functions depending on their type and their location …

The cardiac electrical system is designed to ensure the appropriate rate and timing of
contraction in all regions of the heart, which are essential for effective cardiac function. Well …

Even though sequencing of the mammalian genome has led to the discovery of a large
number of ionic channel genes, identification of the molecular determinants of cellular …

Genetic approaches have succeeded in defining the molecular basis of an increasing array
of heart diseases, such as hypertrophic cardiomyopathy and the long-QT syndromes …

MinK is a widely expressed protein of relative molecular mass∼ 15K that forms potassium
channels by aggregation with other membrane proteins,,. MinK governs ion channel …

K+ channels are widely distributed in both plant and animal cells where they serve many
distinct functions. K+ channels set the membrane potential, generate electrical signals in …

Prolongation of action potential duration is the most consistent electrophysiological
abnormality in myocardium and myocytes from hypertrophied and failing hearts …

1 Ventricular myocytes demonstrate a steeply inwardly rectifying K+ current termed IK1. We
investigated the molecular basis for murine IK1 by removing the genes encoding Kir2. 1 and …

GY Oudit, Z. Kassiri, R. Sah, RJ Ramirez, C. Zobel and PH Backx. The Molecular Physiology
of the Cardiac Transient Outward Potassium Current (Ito) in Normal and Diseased …

At least two functionally distinct transient outward K+ current (Ito) phenotypes can exist
across the free wall of the left ventricle (LV). Based upon their voltage‐dependent kinetics of …