Ischemia/reperfusion injury: a review in relation to free tissue transfers
M Siemionow, E Arslan - Microsurgery: Official Journal of the …, 2004 - Wiley Online Library
Events during ischemia/reperfusion (I/R) injury include: neutrophil‐mediated endothelial
cytotoxicity and activation, generation of free radicals, triggering of cytokines and …
cytotoxicity and activation, generation of free radicals, triggering of cytokines and …
The alternative complement pathway revisited
M Harboe, TE Mollnes - Journal of cellular and molecular …, 2008 - Wiley Online Library
• Introduction• Methods to study and modify the alternative pathway‐Inhibition by
monoclonal antibodies‐Knockout models• Influence of AP amplification on the effect of …
monoclonal antibodies‐Knockout models• Influence of AP amplification on the effect of …
The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation
M Harboe, G Ulvund, L Vien, M Fung… - Clinical & …, 2004 - academic.oup.com
Complement activation with formation of biologically potent mediators like C5a and the
terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and …
terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and …
Closed head injury—an inflammatory disease?
OI Schmidt, CE Heyde, W Ertel, PF Stahel - Brain Research Reviews, 2005 - Elsevier
Closed head injury (CHI) remains the leading cause of death and persisting neurological
impairment in young individuals in industrialized nations. Research efforts in the past years …
impairment in young individuals in industrialized nations. Research efforts in the past years …
Membrane complement regulatory proteins
DD Kim, WC Song - Clinical immunology, 2006 - Elsevier
A number of proteins anchored on the cell surface function to protect host tissues from
bystander injury when complement is activated. In humans, they include decay-accelerating …
bystander injury when complement is activated. In humans, they include decay-accelerating …
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor
SHM Rooijakkers, J Wu, M Ruyken… - Nature …, 2009 - nature.com
Activation of the complement system generates potent chemoattractants and leads to the
opsonization of cells for immune clearance. Short-lived protease complexes cleave …
opsonization of cells for immune clearance. Short-lived protease complexes cleave …
Paths reunited: Initiation of the classical and lectin pathways of complement activation
Understanding the structural organisation and mode of action of the initiating complex of the
classical pathway of complement activation (C1) has been a central goal in complement …
classical pathway of complement activation (C1) has been a central goal in complement …
Profiling of the plasma proteome across different stages of human heart failure
A Egerstedt, J Berntsson, ML Smith, O Gidlöf… - Nature …, 2019 - nature.com
Heart failure (HF) is a major public health problem characterized by inability of the heart to
maintain sufficient output of blood. The systematic characterization of circulating proteins …
maintain sufficient output of blood. The systematic characterization of circulating proteins …
The role of complement in the mechanism of action of rituximab for B-cell lymphoma: implications for therapy
X Zhou, W Hu, X Qin - The oncologist, 2008 - academic.oup.com
Rituximab, a genetically engineered chimeric monoclonal antibody specifically binding to
CD20, was the first antibody approved by the US Food and Drug Administration for the …
CD20, was the first antibody approved by the US Food and Drug Administration for the …
Free radical biology in neurological manifestations: mechanisms to therapeutics interventions
Recent advancements and growing attention about free radicals (ROS) and redox signaling
enable the scientific fraternity to consider their involvement in the pathophysiology of …
enable the scientific fraternity to consider their involvement in the pathophysiology of …