Events during ischemia/reperfusion (I/R) injury include: neutrophil‐mediated endothelial
cytotoxicity and activation, generation of free radicals, triggering of cytokines and …

• Introduction• Methods to study and modify the alternative pathway‐Inhibition by
monoclonal antibodies‐Knockout models• Influence of AP amplification on the effect of …

Complement activation with formation of biologically potent mediators like C5a and the
terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and …

Closed head injury (CHI) remains the leading cause of death and persisting neurological
impairment in young individuals in industrialized nations. Research efforts in the past years …

A number of proteins anchored on the cell surface function to protect host tissues from
bystander injury when complement is activated. In humans, they include decay-accelerating …

Activation of the complement system generates potent chemoattractants and leads to the
opsonization of cells for immune clearance. Short-lived protease complexes cleave …

Understanding the structural organisation and mode of action of the initiating complex of the
classical pathway of complement activation (C1) has been a central goal in complement …

Heart failure (HF) is a major public health problem characterized by inability of the heart to
maintain sufficient output of blood. The systematic characterization of circulating proteins …

Rituximab, a genetically engineered chimeric monoclonal antibody specifically binding to
CD20, was the first antibody approved by the US Food and Drug Administration for the …

Recent advancements and growing attention about free radicals (ROS) and redox signaling
enable the scientific fraternity to consider their involvement in the pathophysiology of …