Permanent hearing loss affects more than 5% of the world's population, yet there are no
nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the …

Epithelial surfaces protect exposed tissues in the body against intrusion of foreign materials,
including xenobiotics, pollen and microbiota. The relative permeability of the various …

The least damaging and most economical method to deliver drugs or carriers into the inner
ear for treatment of disease is through the middle ear. However, the retention of drug in the …

Clustered regularly interspaced short palindromic repeat (CRISPR)/associated protein
(CRISPR/Cas) system is an adaptable immune mechanism used by many bacteria to protect …

The prevalence of ear disorders has spurred efforts to develop drug delivery systems to treat
these conditions. Here, recent advances in drug delivery systems that access the ear …

Hydrogel microrobots have blazed new avenues for local drug administration, while their
values in inner ear drug delivery remain to be explored. Here, novel magnetic alpha‐lipoic …

Effective and safe treatment of auditory and vestibular diseases has become increasingly
dependent on inner ear drug delivery systems. This review highlights recent advances in …

Noise accounts for one-third of hearing loss worldwide. Regretfully, noise-induced hearing
loss (NIHL) is deemed to be irreversible due to the elusive pathogenic mechanisms that …

Meniere's disease (MD) is a severe inner ear condition known by debilitating symptoms,
including spontaneous vertigo, fluctuating and progressive hearing loss, tinnitus, and aural …

Hearing loss caused by aging, noise, cisplatin toxicity, or other insults affects 360 million
people worldwide, but there are no Food and Drug Administration–approved drugs to …