Recognition of tumors by the innate immune system and natural killer cells
A Marcus, BG Gowen, TW Thompson, A Iannello… - Advances in …, 2014 - Elsevier
In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …
explored using a variety of approaches. The roles of the adaptive immune system have been …
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
A Ashkenazi - Nature Reviews Cancer, 2002 - nature.com
Cancer cells often develop resistance to chemotherapy or irradiation through mutations in
the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular …
the p53 tumour-suppressor gene, which prevent apoptosis induction in response to cellular …
Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5
FC Kischkel, DA Lawrence, A Chuntharapai, P Schow… - Immunity, 2000 - cell.com
Abstract Fas (APO-1/CD95) and tumor necrosis factor receptor 1 (TNFR1) trigger apoptosis
by recruiting the apoptosis initiator caspase-8 through the adaptor FADD. Fas binds FADD …
by recruiting the apoptosis initiator caspase-8 through the adaptor FADD. Fas binds FADD …
Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in
various tumor cells in vitro, but its physiological role in tumor surveillance remains unknown …
various tumor cells in vitro, but its physiological role in tumor surveillance remains unknown …
Apo2L/TRAIL and its death and decoy receptors
HN LeBlanc, A Ashkenazi - Cell Death & Differentiation, 2003 - nature.com
Apo2 ligand or tumour necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) is
one of the several members of the tumour necrosis factor (TNF) gene superfamily that …
one of the several members of the tumour necrosis factor (TNF) gene superfamily that …
FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
Apoptosis induced by tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(TRAIL/APO-2L) has been shown to exert important functions during various immunological …
(TRAIL/APO-2L) has been shown to exert important functions during various immunological …
The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems
H Walczak, PH Krammer - Experimental cell research, 2000 - Elsevier
In 1989 we published a paper describing the discovery of an apoptosis-inducing receptor
[1]. We named this receptor APO-1, anticipating that it might be the first of a series of …
[1]. We named this receptor APO-1, anticipating that it might be the first of a series of …
Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy
A Almasan, A Ashkenazi - Cytokine & growth factor reviews, 2003 - Elsevier
Apo2 ligand or tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL)
is one of several members of the TNF gene superfamily that induce apoptosis through …
is one of several members of the TNF gene superfamily that induce apoptosis through …
Human NK cell lytic granules and regulation of their exocytosis
K Krzewski, JE Coligan - Frontiers in immunology, 2012 - frontiersin.org
Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-
surveillance and host defense against cancer and viral infections. They recognize stressed …
surveillance and host defense against cancer and viral infections. They recognize stressed …
Apoptosis-based therapies for hematologic malignancies
JC Reed, M Pellecchia - Blood, 2005 - ashpublications.org
Apoptosis is an intrinsic cell death program that plays critical roles in tissue homeostasis,
especially in organs where high rates of daily cell production are offset by rapid cell …
especially in organs where high rates of daily cell production are offset by rapid cell …