Mechanisms of oocyte aneuploidy associated with advanced maternal age
It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …
Risk factors for Down syndrome
F Coppedè - Archives of toxicology, 2016 - Springer
Down syndrome (DS) originates, in most of the cases (95%), from a full trisomy of
chromosome 21. The remaining cases are due to either mosaicism for chromosome 21 or …
chromosome 21. The remaining cases are due to either mosaicism for chromosome 21 or …
Pre-conception folic acid and multivitamin supplementation for the primary and secondary prevention of neural tube defects and other folic acid-sensitive congenital …
Objective To provide updated information on the pre-and post-conception use of oral folic
acid with or without a multivitamin/micronutrient supplement for the prevention of neural tube …
acid with or without a multivitamin/micronutrient supplement for the prevention of neural tube …
Folic acid supplementation in pregnancy and implications in health and disease
S Barua, S Kuizon, MA Junaid - Journal of biomedical science, 2014 - Springer
Maternal exposure to dietary factors during pregnancy can influence embryonic
development and may modulate the phenotype of offspring through epigenetic …
development and may modulate the phenotype of offspring through epigenetic …
The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defects
F Coppedè - Frontiers in genetics, 2015 - frontiersin.org
Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy
M Enciso, J Sarasa, L Xanthopoulou, S Bristow… - Human genetics, 2016 - Springer
MTHFR is an important enzyme in the metabolism of folic acid and is crucial for reproductive
function. Variation in the sequence of MTHFR has been implicated in subfertility, but …
function. Variation in the sequence of MTHFR has been implicated in subfertility, but …
Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case–control study
RJ Schmidt, Q Niu, DW Eyles, RL Hansen… - Autism …, 2019 - Wiley Online Library
Vitamin D appears essential for normal neurodevelopment and cognitive and behavioral
function. We examined neonatal vitamin D in relation to the child's later diagnosis of autism …
function. We examined neonatal vitamin D in relation to the child's later diagnosis of autism …
Prevention of congenital malformations and other adverse pregnancy outcomes with 4.0 mg of folic acid: community-based randomized clinical trial in Italy and the …
R Bortolus, F Blom, F Filippini, MNM van Poppel… - BMC pregnancy and …, 2014 - Springer
Abstract Background In 2010 a Cochrane review confirmed that folic acid (FA)
supplementation prevents the first-and second-time occurrence of neural tube defects …
supplementation prevents the first-and second-time occurrence of neural tube defects …
[HTML][HTML] The impact of folic acid supplementation on gestational and long term health: Critical temporal windows, benefits and risks
C Silva, E Keating, E Pinto - Porto biomedical journal, 2017 - Elsevier
Maternal folic acid (FA) supplementation is one of the most popular nutritional interventions
during pregnancy for its protective effect against neural tube defects (NTDs). The purposes …
during pregnancy for its protective effect against neural tube defects (NTDs). The purposes …
Periconceptional folic acid supplementation and the risk of spontaneous abortion among women who prepared to conceive: impact of supplementation initiation timing
YY Mao, L Yang, M Li, J Liu, QX Zhu, Y He, WJ Zhou - Nutrients, 2020 - mdpi.com
It is unclear whether periconceptional folic acid (FA) supplementation decreases the risk of
spontaneous abortion (SA). The impact of supplementation initiation timing has not been …
spontaneous abortion (SA). The impact of supplementation initiation timing has not been …