Dengue is a mosquito-borne viral disease (arboviral) caused by the Dengue virus. It is one
of the prominent public health problems in tropical and subtropical regions with no effective …

Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …

The primary interactions between incoming viral RNA genomes and host proteins are crucial
to infection and immunity. Until now, the ability to study these events was lacking. We …

Flaviviruses comprise a genus of viruses that pose a significant burden on human health
worldwide. Transmission by both mosquito and tick vectors, and broad host tropism …

Emerging microbe infections, such as Zika virus (ZIKV), pose an increasing threat to human
health. Investigations on ZIKV replication have revealed the construction of replication …

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic flavivirus that causes
encephalitis and reproductive disorders in mammalian species. However, the host factors …

N-linked glycosylation is the most common form of protein glycosylation and is required for
the proper folding, trafficking, and/or receptor binding of some host and viral proteins. As …

Background Identifying host factors is key to understanding RNA virus pathogenicity.
Besides proteins, RNAs can interact with virus genomes to impact replication. Results Here …

The multi-functional endoplasmic reticulum (ER) is exploited by viruses to cause infection.
Morphologically, this organelle is a highly interconnected membranous network consisting …

Based on genome-scale loss-of-function screens we discovered that Topoisomerase III-β
(TOP3B), a human topoisomerase that acts on DNA and RNA, is required for yellow fever …