[HTML][HTML] PNA clamping in nucleic acid amplification protocols to detect single nucleotide mutations related to cancer
MF Fouz, DH Appella - Molecules, 2020 - mdpi.com
This review describes the application of peptide nucleic acids (PNAs) as clamps that prevent
nucleic acid amplification of wild-type DNA so that DNA with mutations may be observed …
nucleic acid amplification of wild-type DNA so that DNA with mutations may be observed …
Early detection of pre-malignant lesions in a KRASG12D-driven mouse lung cancer model by monitoring circulating free DNA
CP Rakhit, RM Trigg, J Le Quesne… - Disease Models & …, 2019 - journals.biologists.com
Lung cancer is the leading cause of cancer-related death. Two-thirds of cases are
diagnosed at an advanced stage that is refractory to curative treatment. Therefore, strategies …
diagnosed at an advanced stage that is refractory to curative treatment. Therefore, strategies …
[HTML][HTML] Identification of a Clinical Cutoff Value for Multiplex KRASG12/G13 Mutation Detection in Colorectal Adenocarcinoma Patients Using Digital Droplet PCR …
KH Lee, TH Lee, MK Choi, IS Kwon, GE Bae… - Journal of clinical …, 2020 - mdpi.com
KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) is a major predictive marker for anti-
epidermal growth factor receptor treatment, and determination of KRAS mutational status is …
epidermal growth factor receptor treatment, and determination of KRAS mutational status is …
[HTML][HTML] A novel xenonucleic acid-mediated molecular clamping technology for early colorectal cancer screening
Q Sun, L Pastor, J Du, MJ Powell, A Zhang, W Bodmer… - Plos one, 2021 - journals.plos.org
Background Colorectal cancer (CRC) is one of the leading causes of cancer-related death.
Early detection is critical to reduce CRC morbidity and mortality. In order to meet this need …
Early detection is critical to reduce CRC morbidity and mortality. In order to meet this need …
[HTML][HTML] Prognostic value of circulating tumor DNA (ctDNA) in oncogene-driven NSCLC: current knowledge and future perspectives
E Zografos, FI Dimitrakopoulos, A Koutras - Cancers, 2022 - mdpi.com
Simple Summary Personalized medicine has significantly changed the clinical outcome of
oncogene-driven non-small cell lung cancer (NSCLC) due to the efficacy of molecular …
oncogene-driven non-small cell lung cancer (NSCLC) due to the efficacy of molecular …