Forkhead box (Fox) transcription factors are evolutionarily conserved in organisms ranging
from yeast to humans. They regulate diverse biological processes both during development …

Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …

We have produced gene expression profiles of all 302 neurons of the C. elegans nervous
system that match the single-cell resolution of its anatomy and wiring diagram. Our results …

Aging is characterized by a global decline in physiological function. However, by
constructing a complete single-cell gene expression atlas, we find that Caenorhabditis …

Twenty-nine years following the breakthrough discovery that a single-gene mutation of daf-2
doubles Caenorhabditis elegans lifespan, it remains unclear where this insulin/IGF-1 …

The ability to inherit learned information from parents could be evolutionarily beneficial,
enabling progeny to better survive dangerous conditions. We discovered that, after C …

Metabolic dysfunction occurs in many age-related neurodegenerative diseases, yet its role
in disease etiology remains poorly understood. We recently discovered a potential causal …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

It is unknown whether the activity of the nervous system can be inherited. In Caenorhabditis
elegans nematodes, parental responses can transmit heritable small RNAs that regulate …

Autophagy has been linked to longevity in many species, but the underlying mechanisms
are unclear. Using a GFP-tagged and a new tandem-tagged Atg8/LGG-1 reporter, we …