The skeleton is diverse in its functions, which include mechanical support, movement, blood
cell production, mineral storage and endocrine regulation. This multifaceted role is achieved …

Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the
most important functions of these metabolically active cells is mineralized matrix production …

The bone marrow contains various populations of skeletal stem cells (SSCs) in the stromal
compartment, which are important regulators of bone formation. It is well-described that …

Human skeletal stem cells (SSCs) have been discovered in fetal and adult long bones.
However, the spatiotemporal ontogeny of human embryonic SSCs during early …

Human skeletal stem cells (hSSCs) hold tremendous therapeutic potential for developing
new clinical strategies to effectively combat congenital and age-related musculoskeletal …

Bone development and bone remodelling during adult life are highly anabolic processes
requiring an adequate supply of oxygen and nutrients. Bone-forming osteoblasts and bone …

Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly
regulated processes, with SSPC dysregulation leading to progressive bone disease. While …

We have previously reported that the cortical bone thinning seen in mice lacking the Wnt
signaling antagonist Sfrp4 is due in part to impaired periosteal apposition. The periosteum …

The growth plate is an essential component of endochondral bone development. Not
surprisingly, the growth plate and its surrounding structure, the perichondrium, contain a …

Objective This review addresses the latest advances in research on the role of macrophages
in fracture healing, exploring their relationship with failures in bone consolidation and the …