No matter what their origin, strain and family, viruses have evolved exquisite strategies to
reach and penetrate specific target cells where they hijack the cellular machinery to express …

More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

The study of hepatitis C virus (HCV), a major cause of chronic liver disease, has been
hampered by the lack of a cell culture system supporting its replication. Here, we have …

Neurological disorders affecting the central nervous system (CNS) are still incompletely
understood. Many of these disorders lack a cure and are seeking more specific and effective …

In the late 1970s, it was predicted that gene therapy would be applied to humans within a
decade. However, despite some success, gene therapy has still not become a routine …

Lentiviral vectors (LVs) have emerged as potent and versatile vectors for ex vivo or in vivo
gene transfer into dividing and nondividing cells. Robust phenotypic correction of diseases …

Generating lentiviral vectors pseudotyped with different viral glycoproteins (GPs) may
modulate the physicochemical properties of the vectors, their interaction with the host …

Hematopoietic stem cell (HSC)-based gene therapy holds promise for the cure of many
diseases. The field is now moving toward the use of lentiviral vectors (LVs) as evidenced by …

Background Lentiviral vectors have emerged as efficient vehicles for transgene delivery in
both dividing and non-dividing cells. A number of different modifications in vector design …

Viruses have evolved specialized molecular mechanisms to transfer their genome efficiently
into host cells. Viruses can be repurposed into viral vectors to achieve controlled gene …