New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Despite recent changes in the epidemiology of HIV infection and malaria and major
improvements in their control, these diseases remain two of the most important infectious …

This report updates and combines earlier versions of guidelines for the prevention and
treatment of opportunistic infections (OIs) in HIV-infected adults (ie, persons aged> 18 years) …

During their intraerythrocytic development, malaria parasites export hundreds of proteins to
remodel their host cell. Nutrient acquisition, cytoadherence and antigenic variation are …

Malaria has been a human health concern ever since the dawn of mankind, but despite the
huge struggles made to date to fight this infection, in 2012 over half a million people were …

Plasmepsins are a group of diverse aspartic proteases in the malaria parasite Plasmodium.
Their functions are strikingly multifaceted, ranging from hemoglobin degradation to secretory …

Background HIV-1 and malaria are common infections in Africa, and cause substantial
morbidity and mortality. HIV infection has been associated with an increased incidence of …

Malaria is one of the major diseases in the world. Due to the rapid spread of parasite
resistance to available antimalarial drugs there is an urgent need for new antimalarials with …

Discovery and development of antimalarial drugs have long been dominated by single-
target therapy. Continuous effort has been made to explore and identify different targets in …

Background Human immunodeficiency virus (HIV) protease inhibitors show activity against
Plasmodium falciparum in vitro. We hypothesized that the incidence of malaria in HIV …