Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Abstract The E2 factor (E2F) family of transcription factors are downstream targets of the
retinoblastoma protein. E2F factors have been known for several years to be important …

Epigenetic reprogramming is a critical process of pathological gene induction during cardiac
hypertrophy and remodeling, but the underlying regulatory mechanisms remain to be …

The bmi-1 gene was first isolated as an oncogene that cooperates with c-myc in the
generation of mouse lymphomas,. We subsequently identified Bmi-1 as a transcriptional …

Previously we reported that a karyotypically silent t (4; 14)(p16. 3; q32. 3) translocation is
present in about 25% of multiple myeloma (MM) tumors, and causes overexpression of …

Polycomb group protein Ezh2 is an essential epigenetic regulator of embryonic
development in mice, but its role in the adult organism is unknown. High expression of Ezh2 …

The SET domain proteins, SUV39 and G9a have recently been shown to be histone
methyltransferases specific for lysines 9 and 27 (G9a only) of histone 3 (H3). The SET …

Eukaryotic phenotypic diversity arises from multitasking of a core proteome of limited size.
Multitasking is routine in computers, as well as in other sophisticated information systems …

Despite the availability of vaccines, human papillomavirus (HPV) infections remain a cause
of significant cancer morbidity and mortality. We have previously shown that HPV16 E7 …

During vertebrate development, clustered genes from the Hox family of transcription factors
are activated in a precise temporal and spatial sequence that follows their chromosomal …