Environmental contaminants and male infertility: Effects and mechanisms

V Selvaraju, S Baskaran, A Agarwal, R Henkel - Andrologia, 2021 - Wiley Online Library
The escalating prevalence of male infertility and decreasing trend in sperm quality have
been correlated with rapid industrialisation and the associated discharge of an excess of …

[HTML][HTML] Human male genital tract microbiota

A Zuber, A Peric, N Pluchino, D Baud… - International Journal of …, 2023 - mdpi.com
The human body is vastly colonised by microorganisms, whose impact on health is
increasingly recognised. The human genital tract hosts a diverse microbiota, and an …

Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular …

TX Zhao, JK Wang, LJ Shen, CL Long, B Liu, Y Wei… - Environmental …, 2020 - Elsevier
Abstract Di-(2-ethylhexyl) phthalate (DEHP) is a common environmental endocrine
disrupting chemical that may induce male reproductive disorders. Exposure to DEHP at a …

[HTML][HTML] Lifestyle interventions to reduce endocrine-disrupting phthalate and phenol exposures among reproductive age men and women: A review and future steps

L Martin, Y Zhang, O First, V Mustieles, R Dodson… - Environment …, 2022 - Elsevier
Non-persistent endocrine-disrupting chemicals (EDCs), including phthalates and phenols,
are ubiquitous in both the environment and human body. A growing body of epidemiologic …

[HTML][HTML] Semen evaluation: Methodological advancements in sperm quality-specific fertility assessment—A review

BM Tanga, AY Qamar, S Raza, S Bang, X Fang… - Animal …, 2021 - ncbi.nlm.nih.gov
Assessment of male fertility is based on the evaluation of sperm. Semen evaluation
measures various sperm quality parameters as fertility indicators. However, semen …

Multiple transcriptomic profiling: p53 signaling pathway is involved in DEHP-induced prepubertal testicular injury via promoting cell apoptosis and inhibiting cell …

J Wang, T Zhao, J Chen, L Kang, Y Wei, Y Wu… - Journal of hazardous …, 2021 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a widely-used plasticizer and has long been
recognized as an endocrine-disrupting chemical with male reproductive toxicities. DEHP …

[HTML][HTML] Comprehensive analysis of the association between human non-obstructive azoospermia and plasticisers via single-cell and traditional RNA sequencing …

X Zhang, X Ren, T Zhang, X Zhou, X Chen, H Lu… - Exposure and …, 2022 - Springer
A father's lifetime experience is a major risk factor for a range of diseases in an individual.
The influences of exposure can also be transmitted to offspring. Previous studies …

The role of STAT3/p53 and PI3K-Akt-mTOR signaling pathway on DEHP-induced reproductive toxicity in pubertal male rat

G Fu, J Dai, Z Li, F Chen, L Liu, L Yi, Z Teng… - Toxicology and Applied …, 2020 - Elsevier
Abstract Di (2-ethylhexyl) phthalate (DEHP) is a known environmental endocrine disruptor
that impairs development of testis and spermatogenesis. This study aims to explore the …

[HTML][HTML] Metabolomics of human semen: a review of different analytical methods to unravel biomarkers for male fertility disorders

J Blaurock, S Baumann, S Grunewald… - International Journal of …, 2022 - mdpi.com
Background: Human life without sperm is not possible. Therefore, it is alarming that the
fertilizing ability of human spermatozoa is continuously decreasing. The reasons for that are …

Evaluation of the spinal effects of phthalates in a zebrafish embryo assay

L Qian, J Liu, Z Lin, X Chen, L Yuan, G Shen, W Yang… - Chemosphere, 2020 - Elsevier
Phthalates (phthalate esters, PAEs) are commonly used as plasticizers and are emerging
concerns worldwide for their potential influence on the environment and general public …