Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020 - ASPET
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

Epigenetic modifications in stress response genes associated with childhood trauma

S Jiang, L Postovit, A Cattaneo, EB Binder… - Frontiers in …, 2019 - frontiersin.org
Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

Hormonal treatments for major depressive disorder: state of the art

JB Dwyer, A Aftab, R Radhakrishnan… - American Journal of …, 2020 - Am Psychiatric Assoc
Major depressive disorder is a common psychiatric disorder associated with marked
suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030 …

[HTML][HTML] Stress: endocrine physiology and pathophysiology

C Tsigos, I Kyrou, E Kassi, GP Chrousos - Endotext [Internet], 2020 - ncbi.nlm.nih.gov
Stress constitutes a state of threatened homeostasis triggered by intrinsic or extrinsic
adverse forces (stressors) and is counteracted by an intricate repertoire of physiologic and …

The oxytocin–vasopressin pathway in the context of love and fear

CS Carter - Frontiers in endocrinology, 2017 - frontiersin.org
Vasopressin (VP) and oxytocin (OT) are distinct molecules; these peptides and their
receptors [OT receptor (OTR) and V1a receptor (V1aR)] also are evolved components of an …

The HPA axis as target for depression

A Menke - Current Neuropharmacology, 2024 - benthamdirect.com
Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime
prevalence of 20% and, thus, is one of the most prevalent mental health disorders …

[HTML][HTML] The biology of vasopressin

S Sparapani, C Millet-Boureima, J Oliver, K Mu… - Biomedicines, 2021 - mdpi.com
Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin
functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for …

Genetic association studies of alterations in protein function expose recessive effects on cancer predisposition

N Brandes, N Linial, M Linial - Scientific reports, 2021 - nature.com
The characterization of germline genetic variation affecting cancer risk, known as cancer
predisposition, is fundamental to preventive and personalized medicine. Studies of genetic …

Biomarkers associated with cardiovascular disease in COVID-19

CC Kaufmann, A Ahmed, AL Burger, M Muthspiel… - Cells, 2022 - mdpi.com
Coronavirus disease-19 (COVID-19) emerged late December 2019 in the city of Wuhan,
China and has since spread rapidly all over the world causing a global pandemic. While the …

Long-term health outcomes associated with hydration status

NI Dmitrieva, M Boehm, PH Yancey… - Nature Reviews …, 2024 - nature.com
Body water balance is determined by fundamental homeostatic mechanisms that maintain
stable volume, osmolality and the composition of extracellular and intracellular fluids. Water …