The cloning of a G protein-coupled extracellular Ca2+ (Cao 2+)-sensing receptor (CaR) has
elucidated the molecular basis for many of the previously recognized effects of Cao 2+ on …

Ca2+ is well established as an intracellular second messenger. However, the molecular
identification of a detector for extracellular Ca2+—the extracellular calcium-sensing receptor …

Compelling evidence of a cell surface receptor sensitive to extracellular calcium was
observed as early as the 1980s and was finally realized in 1993 when the calcium-sensing …

Abstract The Ca 2+-sensing receptor (CaSR) regulates the calcium homeostasis in the
human body via sensing fluctuations in the extracellular Ca 2+ concentration. Naturally …

The calcium-sensing receptor (CaSR) has played an important role as a target in the
treatment of a variety of disease states over the past 20 plus years. In this review, we give an …

The calcium-sensing receptor (CaR) is activated by small changes in the ionic extracellular
calcium concentration (Ca o) within the physiological range, allowing the parathyroid gland …

Digestion of food and normal salt and water homeostasis in the body require a functional
digestive tract. Recently an increasing number of studies have demonstrated a role for the …

Extracellular Ca2+-sensing receptors (CaRs) are the molecular basis by which specialized
cells detect and respond to changes in the extracellular [Ca2+]([Ca2+] o). CaRs belong to …

To determine whether calcium polyvalent cation-sensing receptors (CaRs) are salinity
sensors in fish, we used a homology-based cloning strategy to isolate a 4.1-kb cDNA …

The gastrointestinal tract is vital to food digestion and nutrient absorption as well as normal
salt and water homeostasis. Studies over the last several years have shown that the Ca2+ …