Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …

Optimal fracture treatment requires knowledge of the complex physiological process of bone
healing. The course of bone healing is mainly influenced by fracture fixation stability …

Patients living with osteoporosis are projected to increase dramatically in the next decade.
Alongside the forecasted increased societal and economic burden, we will live a crisis of …

The Wnt signaling pathway plays an important role not only in embryonic development but
also in the maintenance and differentiation of the stem cells in adulthood. In particular, Wnt …

The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …

WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …

Inhibition of the Wnt antagonist sclerostin increases bone mass in patients with osteoporosis
and in preclinical animal models. Here we show increased levels of the Wnt antagonist …

Delayed healing and nonunion of fractures represent enormous burdens to patients and
healthcare systems. There are currently no approved pharmacological agents for the …

Osteoporosis (OP) is a chronic bone disease characterized by aberrant microstructure and
macrostructure of bone, leading to reduced bone mass and increased risk of fragile …

While century old clinical reports document the periosteum's remarkable regenerative
capacity, only in the past decade have scientists undertaken mechanistic investigations of its …