WNT signaling in bone homeostasis and disease: from human mutations to treatments
R Baron, M Kneissel - Nature medicine, 2013 - nature.com
Low bone mass and strength lead to fragility fractures, for example, in elderly individuals
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …
affected by osteoporosis or children with osteogenesis imperfecta. A decade ago, rare …
Fracture healing under healthy and inflammatory conditions
L Claes, S Recknagel, A Ignatius - Nature Reviews Rheumatology, 2012 - nature.com
Optimal fracture treatment requires knowledge of the complex physiological process of bone
healing. The course of bone healing is mainly influenced by fracture fixation stability …
healing. The course of bone healing is mainly influenced by fracture fixation stability …
Osteoporosis in 10 years time: a glimpse into the future of osteoporosis
Patients living with osteoporosis are projected to increase dramatically in the next decade.
Alongside the forecasted increased societal and economic burden, we will live a crisis of …
Alongside the forecasted increased societal and economic burden, we will live a crisis of …
Wnt signaling in bone formation and its therapeutic potential for bone diseases
JH Kim, X Liu, J Wang, X Chen… - Therapeutic …, 2013 - journals.sagepub.com
The Wnt signaling pathway plays an important role not only in embryonic development but
also in the maintenance and differentiation of the stem cells in adulthood. In particular, Wnt …
also in the maintenance and differentiation of the stem cells in adulthood. In particular, Wnt …
Sclerostin and Dickkopf-1 as therapeutic targets in bone diseases
HZ Ke, WG Richards, X Li, MS Ominsky - Endocrine reviews, 2012 - academic.oup.com
The processes of bone growth, modeling, and remodeling determine the structure, mass,
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …
and biomechanical properties of the skeleton. Dysregulated bone resorption or bone …
The WNT system: background and its role in bone
UH Lerner, C Ohlsson - Journal of internal medicine, 2015 - Wiley Online Library
WNT s are extracellular proteins that activate different cell surface receptors linked to
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …
canonical and noncanonical WNT signalling pathways. The Wnt genes were originally …
[HTML][HTML] A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
M Florio, K Gunasekaran, M Stolina, X Li, L Liu… - Nature …, 2016 - nature.com
Inhibition of the Wnt antagonist sclerostin increases bone mass in patients with osteoporosis
and in preclinical animal models. Here we show increased levels of the Wnt antagonist …
and in preclinical animal models. Here we show increased levels of the Wnt antagonist …
Fracture healing physiology and the quest for therapies for delayed healing and nonunion
P Kostenuik, FM Mirza - Journal of Orthopaedic Research®, 2017 - Wiley Online Library
Delayed healing and nonunion of fractures represent enormous burdens to patients and
healthcare systems. There are currently no approved pharmacological agents for the …
healthcare systems. There are currently no approved pharmacological agents for the …
[HTML][HTML] Recent progresses in the treatment of osteoporosis
SS Li, SH He, PY Xie, W Li, XX Zhang, TF Li… - Frontiers in …, 2021 - frontiersin.org
Osteoporosis (OP) is a chronic bone disease characterized by aberrant microstructure and
macrostructure of bone, leading to reduced bone mass and increased risk of fragile …
macrostructure of bone, leading to reduced bone mass and increased risk of fragile …
Current insights on the regenerative potential of the periosteum: molecular, cellular, and endogenous engineering approaches
While century old clinical reports document the periosteum's remarkable regenerative
capacity, only in the past decade have scientists undertaken mechanistic investigations of its …
capacity, only in the past decade have scientists undertaken mechanistic investigations of its …