Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …

Interleukin-22 (IL-22) is a recently described IL-10 family cytokine that is produced by T
helper (Th) 17 cells, γδ T cells, NKT cells, and newly described innate lymphoid cells (ILCs) …

Background Dupilumab is an IL-4 receptor α mAb inhibiting signaling of IL-4 and IL-13, key
drivers of type 2–driven inflammation, as demonstrated by its efficacy in patients with …

Summary Interleukin (IL)-36α, IL-36β and IL-36γ are expressed highly in skin and are
involved in the pathogenesis of psoriasis, while the antagonists IL-36Ra or IL-38, another …

GAO, Jintao et al. Daphnetin inhibits proliferation and inflammatory response in human
HaCaT keratinocytes and ameliorates imiquimod-induced psoriasis-like skin lesion in mice …

IL-36 cytokines, a subgroup of IL-1 family, comprise IL-36α, IL-36β, and IL-36γ agonists,
abundantly expressed in psoriatic skin, and IL-36RA and IL-38 antagonists. In psoriatic skin …

Summary Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic
inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is …

The development of in vitro and ex vivo models to mimic human illness is important not only
for scientific understanding and investigating therapeutic approaches but also to mitigate …

Interleukin (IL)-38, a newly discovered IL-1 family cytokine, is expressed in several tissues
and secreted by various cells. IL-38 has recently been reported to exert an anti-inflammatory …

Alopecia areata (AA), a prevalent inflammatory cause of hair loss, lacks FDA-approved
therapeutics for extensive cases, which are associated with very poor rates of spontaneous …