Adrenocortical carcinoma (ACC) is a rare endocrine malignancy, often with an unfavorable
prognosis. Here we summarize the knowledge about diagnosis, epidemiology …

Adrenocortical carcinoma (ACC) is a rare and heterogeneous malignancy, and most of the
diagnostic and therapeutic strategies are not fully established according to criteria of …

Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone-producing
tumor with variable prognosis. The purpose of these guidelines is to provide clinicians with …

Origin of the adrenogonadal primordium The adrenal glands develop from 2 separate
embryologic tissues: the medulla is derived from neural crest cells originating in proximity to …

Almost one decade ago, etoposide, doxorubicin, cisplatin and mitotane (EDP-M) has been
established as first-line systemic therapy of metastatic adrenocortical carcinoma (ACC) …

MicroRNAs (miRNAs) act at the posttranscriptional level to control gene expression in
virtually every biological process, including oncogenesis. Here, we report the identification …

BACKGROUND: The authors are interested in identifying molecular markers that can aid in
the diagnosis of adrenocortical carcinoma (ACC). The aim of this study was to identify …

Dysregulation of the WNT and insulin-like growth factor 2 (IGF2) signaling pathways has
been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC) …

Context: Drug therapy for adrenocortical carcinoma (ACC), a rare and lethal malignancy, is
largely empirical and ineffective. New treatments directed at molecular targets critical to the …

The human adrenal cortex secretes mineralocorticoids, glucocorticoids and adrenal
androgens. These steroids are produced from unique cell types located within the three …