Gene therapy represents a potential efficient approach of disease prevention and therapy.
However, due to their poor in vivo stability, gene molecules need to be associated with …

Due to the potential use as transfecting agents of nucleic acids (DNA or RNA), multivalent
cationic non-viral vectors have received special attention in the last decade. Much effort has …

The use of cationic lipids (CLs) as transfecting agents of DNA has received an increasing
attention in the last two decades. In order to improve the transfection efficiency with lower …

For the purpose of systemic delivery of siRNA, we previously developed polycation
liposomes (PCLs) containing dicetylphosphate-tetraethylenepentamine (DCP-TEPA) as an …

Nanocarriers have the capability to deliver a variety of drugs to disease sites. Different
biological barriers prevent the successful delivery of nanoformulations to target sites …

This paper develops a structure− activity relationship understanding of the way in which
surfactant-like dendrons with hydrophilic spermine surface groups and a variety of lipophilic …

Liposomes have been widely used as drug carriers in the field of drug delivery systems
(DDS), and they are thought to be ideal nano-capsules for targeting DDS after being injected …

Several approaches, including plasmid transfection and viral vectors, were used to deliver
genes into cells for therapeutic and experimental purposes. However, due to the limited …

Dicetyl phosphate-tetraethylenepentamine (DCP-TEPA) conjugate was newly synthesized
and formed into liposomes for efficient siRNA delivery. Formulation of DCP-TEPA-based …

The clinical application of gene silencing mediated by small interfering RNA (siRNA) has
been limited by the lack of efficient and safe carriers. Phospholipid modification of low …