Neprilysin inhibitors in heart failure: the science, mechanism of action, clinical studies, and unanswered questions

B Bozkurt, AP Nair, A Misra, CZ Scott, JH Mahar… - Basic to Translational …, 2023 - jacc.org
This article provides a contemporary review and a new perspective on the role of neprilysin
inhibition in heart failure (HF) in the context of recent clinical trials and addresses potential …

Neprilysin inhibition in heart failure: mechanisms and substrates beyond modulating natriuretic peptides

E D'Elia, A Iacovoni, M Vaduganathan… - European journal of …, 2017 - Wiley Online Library
The autonomic nervous system, the renin–angiotensin–aldosterone system, and the
natriuretic peptide system represent critical regulatory pathways in heart failure and as such …

Impact of insulin degrading enzyme and neprilysin in Alzheimer's disease biology: characterization of putative cognates for therapeutic applications

NK Jha, SK Jha, D Kumar, N Kejriwal… - Journal of …, 2015 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative process primarily characterized by
amyloid-β (Aβ) agglomeration, neuroinflammation, and cognitive dysfunction. The prominent …

Targeting and modulation of the natriuretic peptide system in Covid-19: a single or double-edged effect?

HM Al-Kuraishy, AI Al-Gareeb, A Alexiou… - Current Protein and …, 2022 - benthamdirect.com
Natriuretic peptide system (NPS) is a group of peptide hormones or paracrine factors,
including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and natriuretic …

Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury

ZG Wang, A Sharma, L Feng, DF Muresanu… - International Review of …, 2023 - Elsevier
Abstract dl-3-n-Butylphthalide is a potent synthetic Chinese celery extract that is highly
efficient in inducing neuroprotection in concussive head injury (CHI), Parkinson's disease …

Association of MME gene polymorphisms with susceptibility to Alzheimer's disease in an Iranian population

F Khalili-Moghadam, JH Nejad, T Badri, M Sadeghi… - Heliyon, 2024 - cell.com
Background the MME gene encodes a membrane metalloendopeptidase, known as
neprilysin (NEP). There are no reports on the potential implications of MME gene …

Advanced biology students' individual conceptions of scientific researchers after participating in biomedically relevant CRE

AL Waring-Sparks, RA Waring-Sparks… - … of Microbiology and …, 2024 - journals.asm.org
While undergraduate research has been shown to be a high-impact educational practice, it
is logistically impossible for all undergraduate biology majors to have long-term faculty …

[HTML][HTML] Role of angiotensin receptor-neprilysin inhibition in heart failure

SB Prenner, SJ Shah, CW Yancy - Current atherosclerosis reports, 2016 - Springer
Abstract Purpose of Review Numerous evidence-based medical and device therapies
proven to reduce morbidity and mortality have advanced care for heart failure with reduced …

Angiotensin receptor neprilysin inhibitor LCZ696: pharmacology, pharmacokinetics and clinical development

Y Hua, I Wang, B Liu, DJ Kelly, C Reid, D Liew… - Future …, 2017 - Taylor & Francis
Heart failure still has a significant disease burden with poor outcomes worldwide despite
advances in therapy. The standard therapies have been focused on blockade of renin …

Combined neprilysin and RAS inhibition in cardiovascular diseases: a review of clinical studies

R Tummala, R Bhadra, A Gupta… - Journal of Cardiovascular …, 2016 - journals.lww.com
The aim of this comprehensive review article is to emphasize on the possible exploration of
a new therapeutic approach in the management of heart failure (HF) and other …