Neprilysin inhibitors in heart failure: the science, mechanism of action, clinical studies, and unanswered questions
B Bozkurt, AP Nair, A Misra, CZ Scott, JH Mahar… - Basic to Translational …, 2023 - jacc.org
This article provides a contemporary review and a new perspective on the role of neprilysin
inhibition in heart failure (HF) in the context of recent clinical trials and addresses potential …
inhibition in heart failure (HF) in the context of recent clinical trials and addresses potential …
Neprilysin inhibition in heart failure: mechanisms and substrates beyond modulating natriuretic peptides
E D'Elia, A Iacovoni, M Vaduganathan… - European journal of …, 2017 - Wiley Online Library
The autonomic nervous system, the renin–angiotensin–aldosterone system, and the
natriuretic peptide system represent critical regulatory pathways in heart failure and as such …
natriuretic peptide system represent critical regulatory pathways in heart failure and as such …
Impact of insulin degrading enzyme and neprilysin in Alzheimer's disease biology: characterization of putative cognates for therapeutic applications
NK Jha, SK Jha, D Kumar, N Kejriwal… - Journal of …, 2015 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative process primarily characterized by
amyloid-β (Aβ) agglomeration, neuroinflammation, and cognitive dysfunction. The prominent …
amyloid-β (Aβ) agglomeration, neuroinflammation, and cognitive dysfunction. The prominent …
Targeting and modulation of the natriuretic peptide system in Covid-19: a single or double-edged effect?
Natriuretic peptide system (NPS) is a group of peptide hormones or paracrine factors,
including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and natriuretic …
including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and natriuretic …
Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury
ZG Wang, A Sharma, L Feng, DF Muresanu… - International Review of …, 2023 - Elsevier
Abstract dl-3-n-Butylphthalide is a potent synthetic Chinese celery extract that is highly
efficient in inducing neuroprotection in concussive head injury (CHI), Parkinson's disease …
efficient in inducing neuroprotection in concussive head injury (CHI), Parkinson's disease …
Association of MME gene polymorphisms with susceptibility to Alzheimer's disease in an Iranian population
F Khalili-Moghadam, JH Nejad, T Badri, M Sadeghi… - Heliyon, 2024 - cell.com
Background the MME gene encodes a membrane metalloendopeptidase, known as
neprilysin (NEP). There are no reports on the potential implications of MME gene …
neprilysin (NEP). There are no reports on the potential implications of MME gene …
Advanced biology students' individual conceptions of scientific researchers after participating in biomedically relevant CRE
AL Waring-Sparks, RA Waring-Sparks… - … of Microbiology and …, 2024 - journals.asm.org
While undergraduate research has been shown to be a high-impact educational practice, it
is logistically impossible for all undergraduate biology majors to have long-term faculty …
is logistically impossible for all undergraduate biology majors to have long-term faculty …
[HTML][HTML] Role of angiotensin receptor-neprilysin inhibition in heart failure
SB Prenner, SJ Shah, CW Yancy - Current atherosclerosis reports, 2016 - Springer
Abstract Purpose of Review Numerous evidence-based medical and device therapies
proven to reduce morbidity and mortality have advanced care for heart failure with reduced …
proven to reduce morbidity and mortality have advanced care for heart failure with reduced …
Angiotensin receptor neprilysin inhibitor LCZ696: pharmacology, pharmacokinetics and clinical development
Heart failure still has a significant disease burden with poor outcomes worldwide despite
advances in therapy. The standard therapies have been focused on blockade of renin …
advances in therapy. The standard therapies have been focused on blockade of renin …
Combined neprilysin and RAS inhibition in cardiovascular diseases: a review of clinical studies
The aim of this comprehensive review article is to emphasize on the possible exploration of
a new therapeutic approach in the management of heart failure (HF) and other …
a new therapeutic approach in the management of heart failure (HF) and other …