Proteins that self-assemble into polyhedral shell-like structures are useful molecular
containers both in nature and in the laboratory. Here we review efforts to repurpose diverse …

Viruses are nanoscale entities containing a nucleic acid genome encased in a protein shell
called a capsid and in some cases are surrounded by a lipid bilayer membrane. This review …

Self-assembly is widely used by biological systems to build functional nanostructures, such
as the protein capsids of RNA viruses. But because assembly is a collective phenomenon …

Cryo‐transmission electron microscopy (cryo‐TEM or cryo‐EM) and cryo‐electron
tomography (cryo‐ET) offer robust and powerful ways to visualize nanoparticles. These …

Conspectus Viruses are unique among living organisms insofar as they can be reconstituted
“from scratch”, that is, synthesized from purified components. In the simplest cases, their …

Understanding the pathways by which viral capsid proteins assemble around their genomes
could identify key intermediates as potential drug targets. In this work, we use computer …

An important goal of systems and synthetic biology is to produce high value chemical
species in large quantities. Microcompartments, which are protein nanoshells encapsulating …

The organization of protein molecules into higher-order nanoscale architectures is
ubiquitous in Nature and represents an important goal in synthetic biology. Furthermore, the …

As biological agents, viruses come in an astounding range of sizes, with varied shapes and
surface morphologies. The structures of viral capsids are generally assemblies of hundreds …

For many viruses, capsids (biological nanoparticles) assemble to protect genetic material
and dissociate to release their cargo. To understand these contradictory properties, we …