Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer
AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …
urgent due to the development of malignancies that are resistant to chemotherapeutic …
Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma
MF Mohamed, NS Ibrahim, AA Saddiq… - Scientific Reports, 2023 - nature.com
A novel series of α-cyano indolylchalcones was prepared, and their chemical structures
were confirmed based on the different spectral data. Among them, compound 7f was …
were confirmed based on the different spectral data. Among them, compound 7f was …
Current scenario of chalcone hybrids with antibreast cancer therapeutic applications
H Wang, J Zhu, Q Zhang, J Tang… - Archiv der …, 2024 - Wiley Online Library
Breast cancer, an epithelial malignant tumor that occurs in the terminal ducts of the breast, is
the most common female malignancy. Currently, approximately 70%–80% of breast cancer …
the most common female malignancy. Currently, approximately 70%–80% of breast cancer …
Novel Tetrahydro-[1,2,4]triazolo[3,4-a]isoquinoline Chalcones Suppress Breast Carcinoma through Cell Cycle Arrests and Apoptosis
MIM Darwish, AM Moustafa, AM Youssef, M Mansour… - Molecules, 2023 - mdpi.com
Chalcones are interesting anticancer drug candidates which have attracted much interest
due to their unique structure and their extensive biological activity. Various functional …
due to their unique structure and their extensive biological activity. Various functional …
Synthesis, cytotoxicity, anti-inflammatory, anti-metastatic and anti-oxidant activities of novel chalcones incorporating 2-phenoxy-N-arylacetamide and thiophene …
Eight Novel chalcones were synthesized and their structures were confirmed by different
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
spectral tools. All the prepared compounds were subjected to SRB cytotoxic screening …
Theoretical and molecular mechanistic investigations of novel (3-(furan-2-yl) pyrazol-4-yl) chalcones against lung carcinoma cell line (A549)
MF Mohamed, NS Ibrahim, AA Saddiq… - Naunyn-Schmiedeberg's …, 2023 - Springer
A new chalcone series has been developed that may be useful in the treatment of lung
cancer. The new series was confirmed by the different spectral tools. MTT assay was used to …
cancer. The new series was confirmed by the different spectral tools. MTT assay was used to …
4-Nitrochalcone as a potential drug in non-clinical breast cancer studies
CM Galindo, L Milani, LTF de Lima, ER Adami… - Chemico-Biological …, 2024 - Elsevier
Breast cancer is a high-magnitude public health problem, continually challenging physicians
and scientists worldwide in the field of drug therapy. 4-nitrochalcone (4NC) is a phenolic …
and scientists worldwide in the field of drug therapy. 4-nitrochalcone (4NC) is a phenolic …
Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment
IAY Ghannam, IH Ali, RZ Batran, MT Abo-elfadl… - Medicinal Chemistry …, 2024 - Springer
In this study, chalcones 5, and 6 and pyrazolines 7, and 8 were designed and synthesized
as combrestatin A-4 (CA-4) analogues. The anticancer effect of the synthesized compounds …
as combrestatin A-4 (CA-4) analogues. The anticancer effect of the synthesized compounds …