Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell
populations. Its main biological function seems to be the limitation and termination of …

Chronic gastritis induced by Helicobacter pylori is the strongest known risk factor for
adenocarcinoma of the distal stomach, yet only a minority of people who harbour this …

Helicobacter pylori infection is associated with a variety of clinical outcomes including
gastric cancer and duodenal ulcer disease. The reasons for this variation are not clear, but …

The allele frequency net database (http://www. allelefrequencies. net) is an online repository
that contains information on the frequencies of immune genes and their corresponding …

Polymorphisms of interleukin-1β (IL-1β) are associated with an increased risk of solid
malignancies. Here, we show that stomach-specific expression of human IL-1β in transgenic …

The process of maintaining life for the individual is a constant struggle to preserve his/her
integrity. This can come at a price when immunity is involved, namely systemic inflammation …

Cytokines, signaling proteins produced by a variety of cell types, are essential for the
development and functioning of both innate and adaptive immune response. Cytokine gene …

At least 20 different chromosomal regions have been linked to type 1 diabetes (T1D)
susceptibility in humans, using genome screening, candidate gene testing, and studies of …

Background Polymorphisms in cytokine genes can influence immune responses,
inflammation, and tissue injury and may affect the outcome of hematopoietic stem-cell …

Obesity is a major risk factor for type 2 diabetes mellitus (T2DM), which is a significant health
problem worldwide. Active disease is associated with low-grade chronic inflammation …