Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

Mild traumatic brain injury (mTBI) represents a significant public healthcare concern,
accounting for the majority of all head injuries. While symptoms are generally transient …

Mononuclear phagocytes are a population of multi-phenotypic cells and have dual roles in
brain destruction/reconstruction. The phenotype-specific roles of microglia/macrophages in …

The amyloid hypothesis (AH) of Alzheimer's disease (AD) posits that the fundamental cause
of AD is the accumulation of the peptide amyloid beta (Aβ) in the brain. This hypothesis has …

With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …

Diffuse axonal injury (DAI) remains a prominent feature of human traumatic brain injury (TBI)
and a major player in its subsequent morbidity. The importance of this widespread axonal …

Rapid triage and decision‐making in the treatment of traumatic brain injury (TBI) present
challenging dilemma in “resource poor” environments such as the battlefield and developing …

Explosive blast has been extensively used as a tactical weapon in Operation Iraqi Freedom
(OIF) and more recently in Operation Enduring Freedom (OEF). The polytraumatic nature of …

The family of calcium-activated neutral proteases, calpains, appears to play a key role in
neuropathologic events following traumatic brain injury (TBI). Neuronal calpain activation …

Wolfram syndrome is a genetic disorder characterized by diabetes and neurodegeneration
and considered as an endoplasmic reticulum (ER) disease. Despite the underlying …