Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

Extracellular matrix (ECM) is a non-cellular three-dimensional macromolecular network
composed of collagens, proteoglycans/glycosaminoglycans, elastin, fibronectin, laminins …

The relationship between chronic inflammation and neoplastic diseases is not fully
understood. The inflammatory microenvironment of a tumor is an intricate network that …

Inflammatory cytokines are highly inducible small glycoproteins or regulatory proteins of low
molecular weight secreted by different cell types. They regulate intercellular communication …

For almost four decades, my work has focused on one challenge: improving the delivery and
efficacy of anticancer therapeutics. Working on the hypothesis that the abnormal tumor …

New vessel formation (angiogenesis) is an essential physiological process for embryologic
development, normal growth, and tissue repair. Angiogenesis is tightly regulated at the …

Malignant ascites presents a considerable clinical challenge to the management of ovarian
cancer, but also provides a wealth of opportunities for translational research. The …

In ovarian cancer patients, tumor fibrosis and angiotensin-driven fibrogenic signaling have
been shown to inversely correlate with survival. We sought to enhance drug delivery and …

Background In advanced cancers, transforming growth factor-beta (TGFβ) promotes tumor
growth and metastases and suppresses host antitumor immunity. GC1008 is a human anti …

Pathological angiogenesis—driven by an imbalance of pro-and antiangiogenic signaling—
is a hallmark of many diseases, both malignant and benign. Unlike in the healthy adult in …