How softness matters in soft nanogels and nanogel assemblies

A Scotti, MF Schulte, CG Lopez, JJ Crassous… - Chemical …, 2022 - ACS Publications
Softness plays a key role in determining the macroscopic properties of colloidal systems,
from synthetic nanogels to biological macromolecules, from viruses to star polymers …

Insight into cellular uptake and intracellular trafficking of nanoparticles

P Foroozandeh, AA Aziz - Nanoscale research letters, 2018 - Springer
Nanoparticle science is rapidly changing the landscape of various scientific fields and
defining new technological platforms. This is perhaps even more evident in the field of …

[HTML][HTML] Endocytosis: the nanoparticle and submicron nanocompounds gateway into the cell

D Manzanares, V Ceña - Pharmaceutics, 2020 - mdpi.com
Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering
therapeutic compounds to cells. Their entry into the cell represents the initial step in this …

Nanoparticle elasticity affects systemic circulation lifetime by modulating adsorption of apolipoprotein AI in corona formation

M Li, X Jin, T Liu, F Fan, F Gao, S Chai… - Nature communications, 2022 - nature.com
Nanoparticle elasticity is crucial in nanoparticles' physiological fate, but how this occurs is
largely unknown. Using core-shell nanoparticles with a same PEGylated lipid bilayer shell …

Role of nanoparticle mechanical properties in cancer drug delivery

Y Hui, X Yi, F Hou, D Wibowo, F Zhang, D Zhao… - ACS …, 2019 - ACS Publications
The physicochemical properties of nanoparticles play critical roles in regulating nano-bio
interactions. Whereas the effects of the size, shape, and surface charge of nanoparticles on …

Understanding the extracellular vesicle surface for clinical molecular biology

S Hallal, Á Tűzesi, GE Grau… - Journal of …, 2022 - Wiley Online Library
Extracellular vesicles (EVs) are lipid‐membrane enclosed nanoparticles that play significant
roles in health and disease. EVs are abundant in body fluids and carry an array of molecules …

Engineered strategies to enhance tumor penetration of drug-loaded nanoparticles

M Souri, M Soltani, FM Kashkooli… - Journal of Controlled …, 2022 - Elsevier
Nanocarriers have been widely employed in preclinical studies and clinical trials for the
delivery of anticancer drugs. The most important causes of failure in clinical translation of …

Nanoparticle elasticity directs tumor uptake

P Guo, D Liu, K Subramanyam, B Wang, J Yang… - Nature …, 2018 - nature.com
To date, the role of elasticity in drug delivery remains elusive due to the inability to measure
microscale mechanics and alter rheology without affecting chemistry. Herein, we describe …

Nanogels: An overview of properties, biomedical applications and obstacles to clinical translation

KS Soni, SS Desale, TK Bronich - Journal of Controlled Release, 2016 - Elsevier
Nanogels have emerged as a versatile hydrophilic platform for encapsulation of guest
molecules with a capability to respond to external stimuli that can be used for a multitude of …

Nanoparticles and innate immunity: new perspectives on host defence

D Boraschi, P Italiani, R Palomba, P Decuzzi… - Seminars in …, 2017 - Elsevier
The innate immune system provides the first line of defence against foreign microbes and
particulate materials. Engineered nanoparticles can interact with the immune system in …