Abstract Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global …

Organoids represent one of the most important advancements in the field of stem cells
during the past decade. They are three-dimensional in vitro culturing models that originate …

The derivation of tissue-specific stem cells from human induced pluripotent stem cells
(iPSCs) would have broad reaching implications for regenerative medicine. Here, we report …

Alveolar epithelial type II cells (AEC2s) are the facultative progenitors of lung alveoli and
serve as the surfactant-producing cells of air-breathing organisms. Although primary human …

A hallmark of severe COVID-19 pneumonia is SARS-CoV-2 infection of the facultative
progenitors of lung alveoli, the alveolar epithelial type 2 cells (AT2s). However, inability to …

Efficient generation of human induced pluripotent stem cell (hiPSC)-derived human
intestinal organoids (HIOs) would facilitate the development of in vitro models for a variety of …

Organoids derived from stem cells or tissues in culture can develop into structures that
resemble the in vivo anatomy and physiology of intact organs. Human organoid cultures …

The ability to replace defective cells in an airway with cells that can engraft, integrate, and
restore a functional epithelium could potentially cure a number of lung diseases. Progress …

Lung fibrosis is a complex process, with unknown underlying mechanisms, involving various
triggers, diseases and stimuli. Different cell types (epithelial cells, endothelial cells …

Lung diseases occupy a leading position in human morbidity and are the third leading
cause of death. Often the chronic forms of these diseases do not respond to therapy, so that …