Iron fulfils a central role in many essential biochemical processes in human physiology; thus,
proper processing of iron is crucial. Although iron metabolism is subject to relatively strict …

Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease
(AD); the ε4 allele increases risk and the ε2 allele is protective. In the central nervous system …

Rift Valley fever virus (RVFV) is a zoonotic pathogen with pandemic potential. RVFV entry is
mediated by the viral glycoprotein (Gn), but host entry factors remain poorly defined. Our …

According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–
related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to …

The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is
probably influenced by both genetic and environmental risk factors. A strong genetic risk …

Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP) 1
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the …

Oncogene-induced cellular senescence constitutes a strong anti-proliferative response,
which can be set in motion following either oncogene activation or loss of tumour suppressor …

The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

The molecular mechanisms that finely co‐ordinate fibrin formation and fibrinolysis are now
well defined. The structure and function of all major fibrinolytic proteins, which include serine …