Cortical-subcortical interactions in goal-directed behavior

KG Cruz, YN Leow, NM Le, E Adam… - Physiological …, 2023 - journals.physiology.org
Flexibly selecting appropriate actions in response to complex, ever-changing environments
requires both cortical and subcortical regions, which are typically described as participating …

The superior colliculus: cell types, connectivity, and behavior

X Liu, H Huang, TP Snutch, P Cao, L Wang… - Neuroscience Bulletin, 2022 - Springer
The superior colliculus (SC), one of the most well-characterized midbrain sensorimotor
structures where visual, auditory, and somatosensory information are integrated to initiate …

Striatal indirect pathway mediates exploration via collicular competition

J Lee, BL Sabatini - Nature, 2021 - nature.com
The ability to suppress actions that lead to a negative outcome and explore alternative
actions is necessary for optimal decision making. Although the basal ganglia have been …

Diverse inhibitory projections from the cerebellar interposed nucleus

EN Judd, SM Lewis, AL Person - Elife, 2021 - elifesciences.org
The cerebellum consists of parallel circuit modules that contribute to diverse behaviors,
spanning motor to cognitive. Recent work employing cell-type-specific tracing has identified …

Superior colliculus bidirectionally modulates choice activity in frontal cortex

A Thomas, W Yang, C Wang, SL Tipparaju… - Nature …, 2023 - nature.com
Action selection occurs through competition between potential choice options. Neural
correlates of choice competition are observed across frontal cortex and downstream …

Pathway-specific inputs to the superior colliculus support flexible responses to visual threat

C Li, NK Kühn, I Alkislar, A Sans-Dublanc… - Science …, 2023 - science.org
Behavioral flexibility requires directing feedforward sensory information to appropriate
targets. In the superior colliculus, divergent outputs orchestrate different responses to visual …

Approaches to understanding multisensory dysfunction in autism spectrum disorder

JK Siemann, J Veenstra‐VanderWeele… - Autism …, 2020 - Wiley Online Library
Abnormal sensory responses are a DSM‐5 symptom of autism spectrum disorder (ASD),
and research findings demonstrate altered sensory processing in ASD. Beyond difficulties …

The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice

M Huang, D Li, X Cheng, Q Pei, Z Xie, H Gu… - Nature …, 2021 - nature.com
Appetitive locomotion is essential for animals to approach rewards, such as food and prey.
The neuronal circuitry controlling appetitive locomotion is unclear. In a goal-directed …

[HTML][HTML] The caudal prethalamus: Inhibitory switchboard for behavioral control?

A Fratzl, SB Hofer - Neuron, 2022 - cell.com
Prethalamic nuclei in the mammalian brain include the zona incerta, the ventral lateral
geniculate nucleus, and the intergeniculate leaflet, which provide long-range inhibition to …

Recent advances in the understanding of specific efferent pathways emerging from the cerebellum

S Kang, S Jun, SJ Baek, H Park, Y Yamamoto… - Frontiers in …, 2021 - frontiersin.org
The cerebellum has a long history in terms of research on its network structures and motor
functions, yet our understanding of them has further advanced in recent years owing to …