There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …

Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

Histone acetylation is a prominent epigenetic modification of the central nervous system that
is unequivocally associated with an increase in the rate of gene transcription. Because gene …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

Schizophrenia is regarded as a neurodevelopmental disorder with its course progressing
throughout life. However, the aetiology and development of schizophrenia are still under …

Schizophrenia is a devastating disease that arises on the background of genetic
predisposition and environmental risk factors, such as early life stress (ELS). In this study …

Alzheimer's disease (AD) is the most common type of dementia in the elderly. It is
characterized by the deposition of two forms of aggregates within the brain, the amyloid β …

Synaptic deficit-induced excitation and inhibition (E/I) imbalance have been implicated in the
pathogenesis of schizophrenia. Using in vivo two-photon microscopy, we examined the …

Epigenetic processes have profound influence on gene translation and play a key role in
embryonic development and tissue type specification. Recent advances in our …