The worldwide incidence of obesity and its sequelae, such as type 2 diabetes mellitus, have
reached pandemic levels. Central to the development of these metabolic disorders is …

Rationale: Long-term exercise provides reliable cardioprotection via mechanisms still
incompletely understood. Although traditionally considered a thermogenic tissue, brown …

Background: Brown adipose tissue (BAT) is an important tissue for thermogenesis, making it
a potential target to decrease the risks of obesity, type 2 diabetes, and cardiovascular …

White adipose tissue (WAT) is important for metabolic homeostasis. We established the
differential proteomic signatures of WAT in glucose-tolerant lean and obese individuals and …

Key points Mice are commonly housed at room temperatures below their thermoneutral
zone meaning they are exposed to chronic thermal stress. Endurance exercise induces …

Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that
regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex …

Regular exercise promotes whole-body health and prevents disease, yet the underlying
molecular mechanisms throughout a whole organism are incompletely understood. Here …

The differential associations of adipose depots with metabolic risk during obesity have been
proposed to be controlled by environmental and genetic factors. We evaluated the regional …

Exercise increases browning of white adipose tissue (WAT) however, the mechanisms
remain unclear. A factor that is released with exercise, brain derived neurotrophic factor …

Mice are the most commonly used model organism of human biology, especially for
research into the effects of environmental and pharmacological perturbations such as …