Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Genetic-based methods offer environmentally friendly species-specific approaches for
control of insect pests. One method, CRISPR homing gene drive that target genes essential …

Mosquitoes bring global health problems by transmitting parasites and viruses such as
malaria and dengue. Unfortunately, current insecticide-based control strategies are only …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

A recurring target-site mutation identified in various pests and disease vectors alters the
voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or …

Population-scale genome modification can alter the composition or fate of wild populations.
Synthetic gene drives provide one set of tools, but their use is complicated by scientific …

Promising to provide powerful genetic control tools, gene drives have been constructed in
multiple dipteran insects, yeast, and mice for the purposes of population elimination or …

CRISPR homing gene drives can suppress pest populations by targeting female fertility
genes, converting wild-type alleles into drive alleles in the germline of drive heterozygotes …

CRISPR-based homing gene drives can be designed to disrupt essential genes whilst
biasing their own inheritance, leading to suppression of mosquito populations in the …