Estrogen receptors alpha (ERα) and beta (ERβ): subtype-selective ligands and clinical potential
I Paterni, C Granchi, JA Katzenellenbogen, F Minutolo - Steroids, 2014 - Elsevier
Estrogen receptors alpha (ERα) and beta (ERβ) are nuclear transcription factors that are
involved in the regulation of many complex physiological processes in humans. Modulation …
involved in the regulation of many complex physiological processes in humans. Modulation …
Human tumor xenograft models for preclinical assessment of anticancer drug development
J Jung - Toxicological research, 2014 - Springer
Xenograft models of human cancer play an important role in the screening and evaluation of
candidates for new anticancer agents. The models, which are derived from human tumor cell …
candidates for new anticancer agents. The models, which are derived from human tumor cell …
Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study
R Li, C Guo, Y Li, Z Qin, W Huang - Briefings in bioinformatics, 2021 - academic.oup.com
Sepsis is a life-threatening complication of pneumonia, including coronavirus disease-2019
(COVID-19)-induced pneumonia. Evidence of the benefits of vitamin C (VC) for the treatment …
(COVID-19)-induced pneumonia. Evidence of the benefits of vitamin C (VC) for the treatment …
Natural inhibitors of PI3K/AKT signaling in breast cancer: emphasis on newly-discovered molecular mechanisms of action
Epidermal growth factor receptor (EGFR) plays a critical role in the initiation and progression
of a variety of human cancers, including breast cancer. An important signaling pathway …
of a variety of human cancers, including breast cancer. An important signaling pathway …
Network pharmacology-and molecular simulation-based exploration of therapeutic targets and mechanisms of heparin for the treatment of sepsis/COVID-19
Y Fang, S Lin, Q Dou, J Gui, W Li, H Tan… - Journal of …, 2023 - Taylor & Francis
Critically infected patients with COVID-19 (coronavirus disease 2019) are prone to develop
sepsis-related coagulopathy as a result of a robust immune response. The mechanism …
sepsis-related coagulopathy as a result of a robust immune response. The mechanism …
Saraca indica Bark Extract Shows In Vitro Antioxidant, Antibreast Cancer Activity and Does Not Exhibit Toxicological Effects
Medicinal plants are used as a complementary and alternative medicine in treatment of
various diseases including cancer worldwide, because of their ease of accessibility and cost …
various diseases including cancer worldwide, because of their ease of accessibility and cost …
High EMT signature score of invasive non-small cell lung cancer (NSCLC) cells correlates with NFκB driven colony-stimulating factor 2 (CSF2/GM-CSF) secretion by …
A Rudisch, MR Dewhurst, LG Horga, N Kramer… - PloS one, 2015 - journals.plos.org
We established co-cultures of invasive or non-invasive NSCLC cell lines and various types
of fibroblasts (FBs) to more precisely characterize the molecular mechanism of tumor-stroma …
of fibroblasts (FBs) to more precisely characterize the molecular mechanism of tumor-stroma …
The Role of the Dysfunctional Akt‐Related Pathway in Cancer: Establishment and Maintenance of a Malignant Cell Phenotype, Resistance to Therapy, and Future …
G Romano - Scientifica, 2013 - Wiley Online Library
Akt serine/threonine kinases, or PKB, are key players in the regulation of a wide variety of
cellular activities, such as growth, proliferation, protection from apoptotic injuries, control of …
cellular activities, such as growth, proliferation, protection from apoptotic injuries, control of …
Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell …
The anti-cancer property of curcumin, an active component of turmeric, is limited due to its
poor solubility, stability and bioavailability. To enhance its efficacy, we designed a novel …
poor solubility, stability and bioavailability. To enhance its efficacy, we designed a novel …
CD166 positively regulates MCAM via inhibition to ubiquitin E3 ligases Smurf1 and βTrCP through PI3K/AKT and c-Raf/MEK/ERK signaling in Bel-7402 hepatocellular …
X Tang, X Chen, Y Xu, Y Qiao, X Zhang, Y Wang… - Cellular …, 2015 - Elsevier
Abstract Both Cluster of Differentiation 166 (CD166) and Melanoma Cell Adhesion Molecule
(MCAM) play critical roles in maintaining transformative phenotype of Hepatocellular …
(MCAM) play critical roles in maintaining transformative phenotype of Hepatocellular …