Despite recent advances in molecularly targeted therapies and immunotherapies, the
effective treatment of advanced-stage cancers remains a largely unmet clinical need …

The gastrointestinal tract is characterized by a self-renewing epithelium fueled by adult stem
cells residing at the bottom of the intestinal crypt and gastric glands. Their activity and …

Recurrent and hormone-refractory prostate cancer (PCA) exhibits aggressive behaviors
while current therapeutic approaches show little effect of prolonging the survival of patients …

Background and aim Hepatocellular carcinoma (HCC) is a major cause of cancer mortality
and is increasing incidence worldwide. The aim of this study was to identify the key genes …

Hepatocellular carcinoma (HCC) is one of the most fatal cancers worldwide. In this article,
we show that expression of abnormal spindle‐like microcephaly‐associated protein (ASPM) …

Simple Summary Therapy resistance represents one of the major obstacles to curing cancer.
Particular populations of tumor cells, known as cancer stem cells, are responsible for this …

Increasing evidence has indicated that the disorganized expression of certain genes
promotes tumour progression. In this study, we elucidate the potential key differentially …

Osteosarcoma (OS) is the most common primary bone tumor, whose poor prognosis is
mainly due to lung metastasis. The aim of this study is to build a practical and valid …

The existence of heterogeneity has plunged cancer treatment into a challenging dilemma.
We profiled malignant epithelial cells from 5 gastric adenocarcinoma patients through single …

Background Gastric cancer (GC) is the third leading cause of cancer mortality globally and a
molecularly heterogeneous disease. Identifying the driver pathways in GC progression is …