Protein secretion is an essential process for living organisms. In eukaryotes, this
encompasses numerous steps mediated by several hundred cellular proteins. The core …

Vesicles that are generated by endocytic events at the plasma membrane are destined to
early endosomes. A prerequisite for proper fusion is the tethering of two membrane entities …

Lipid mobilization through fatty acid β-oxidation is a central process essential for energy
production during nutrient shortage. In yeast, this catabolic process starts in the peroxisome …

Vesicle trafficking is essential for the generation of asymmetries, which are central to
multicellular development. Core components of the vesicle transport machinery, such as …

Lipid droplet is a cellular organelle with a neutral lipid core surrounded by a phospholipid
monolayer and coated with structural as well as functional proteins. The determination of …

Endocytosis of glycosylphosphatidyl inositol (GPI)-anchored proteins (GPI-APs) and the fluid
phase takes place primarily through a dynamin-and clathrin-independent, Cdc42-regulated …

Arf GTP-binding proteins regulate membrane traffic and actin remodeling. Similar to other
GTP-binding proteins, a complex of Arf–GTP with an effector protein mediates Arf function …

The ADP-ribosylation factor (Arf) Arf GTPase-activating proteins (GAPs) are a family of
proteins that induce hydrolysis of GTP bound to Arf. A conserved domain containing a zinc …

Infection response and other immunity-linked genes (ILGs) were first named in
Caenorhabditis elegans–based expression after pathogen challenge, but many are also up …

The selective transfer of material between membrane-delimited organelles is mediated by
protein-coated vesicles. In many instances, formation of membrane trafficking intermediates …