The nervous system equips us with capability to adapt to many conditions and
circumstances. We rely on an armamentarium of intricately formed neural circuits for many of …

MicroRNAs (miRNAs) are a class of small regulatory RNAs involved in gene regulation. The
regulation is effected by either translational inhibition or transcriptional silencing. In …

During mouse embryonic development, neural progenitors lengthen the G1 phase of the cell
cycle and this has been suggested to be a cause, rather than a consequence, of …

Neurogenesis during the development of the mammalian cerebral cortex involves a switch
of neural stem and progenitor cells from proliferation to differentiation. To explore the …

Neuronal activity enhances the elaboration of newborn neurons as they integrate into the
synaptic circuitry of the adult brain. The role microRNAs play in the transduction of neuronal …

MicroRNAs (miRNAs) are rapidly emerging as a new layer of regulation of mammalian brain
development. However, most of the miRNA target genes remain unidentified. Here, we …

Current antiviral therapies cannot cure hepatitis B virus (HBV) infection; successful HBV
eradication would require inactivation of the viral genome, which primarily persists in host …

Idiopathic epilepsies (IEs) are a group of disorders characterized by recurrent seizures in the
absence of detectable brain lesions or metabolic abnormalities. IEs include common …

During brain wiring, cue-induced axon behaviors such as directional steering and branching
are aided by localized mRNA translation. Different guidance cues elicit translation of subsets …

microRNAs (miRNAs) represent∼ 4% of the genes in vertebrates, where they regulate
deadenylation, translation, and decay of the target messenger RNAs (mRNAs). The …