[HTML][HTML] Extrachromosomal circular DNA in cancer: history, current knowledge, and methods
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
molecule found in all tested eukaryotes. eccDNA plays important roles in cancer …
Reconfigurable A-motif, i-motif and triplex nucleic acids for smart pH-responsive DNA hydrogels
Integrating dynamic reconfigurable DNA crosslinking units, smart DNA hydrogels have
demonstrated sol–gel transition, shape memory, self-healing, sensing, cargo encapsulation …
demonstrated sol–gel transition, shape memory, self-healing, sensing, cargo encapsulation …
Label-free imaging of DNA interactions with 2D materials
Two-dimensional (2D) materials offer potential as substrates for biosensing devices, as their
properties can be engineered to tune interactions between the surface and biomolecules …
properties can be engineered to tune interactions between the surface and biomolecules …
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
L Yang, R Jia, T Ge, S Ge, A Zhuang, P Chai… - Signal transduction and …, 2022 - nature.com
Extrachromosomal circular DNA (eccDNA), ranging in size from tens to millions of base
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …
pairs, is independent of conventional chromosomes. Recently, eccDNAs have been …
Rolling circle RNA synthesis catalyzed by RNA
RNA-catalyzed RNA replication is widely considered a key step in the emergence of life's
first genetic system. However, RNA replication can be impeded by the extraordinary stability …
first genetic system. However, RNA replication can be impeded by the extraordinary stability …
A molecular view of DNA flexibility
DNA dynamics can only be understood by taking into account its complex mechanical
behavior at different length scales. At the micrometer level, the mechanical properties of …
behavior at different length scales. At the micrometer level, the mechanical properties of …
[HTML][HTML] Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in comparative morphometric atomic …
The presence of amyloid fibrils is a hallmark of more than 50 human disorders, including
neurodegenerative diseases and systemic amyloidoses. A key unresolved challenge in …
neurodegenerative diseases and systemic amyloidoses. A key unresolved challenge in …
Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations
K Ahmad, A Javed, C Lanphere, PV Coveney… - Nature …, 2023 - nature.com
DNA can be folded into rationally designed, unique, and functional materials. To fully realise
the potential of these DNA materials, a fundamental understanding of their structure and …
the potential of these DNA materials, a fundamental understanding of their structure and …
Mechanical determinants of chromatin topology and gene expression
The compaction of linear DNA into micrometer-sized nuclear boundaries involves the
establishment of specific three-dimensional (3D) DNA structures complexed with histone …
establishment of specific three-dimensional (3D) DNA structures complexed with histone …
Three-dimensional genome organization via triplex-forming RNAs
An increasing number of long noncoding RNAs (lncRNAs) have been proposed to act as
nuclear organization factors during interphase. Direct RNA-DNA interactions can be …
nuclear organization factors during interphase. Direct RNA-DNA interactions can be …