Kir6. 1 and SUR2 are subunits of ATP-sensitive potassium (KATP) channels expressed in a
wide range of tissues. Extensive study has implicated roles of these channel subunits in …

Bisphosphonates (BPs) are the most used bone-specific anti-resorptive agents, often
chosen as first-line therapy in several bone diseases characterized by an imbalance …

Elevated blood glucose levels, or hyperglycemia, can increase brain excitability and amyloid-
β (Aβ) release, offering a mechanistic link between type 2 diabetes and Alzheimer's disease …

Vascular tone is dependent on smooth muscle KATP channels comprising pore-forming
Kir6. 1 and regulatory SUR2B subunits, in which mutations cause Cantú syndrome. Unique …

KATP channels function as negative regulators of active lymphatic pumping and lymph
transport. This review summarizes and critiques the evidence for the expression of specific …

Ubiquitously expressed throughout the body, ATP-sensitive potassium (KATP) channels
couple cellular metabolism to electrical activity in multiple tissues; their unique assembly as …

Decreased or increased activity of potassium channels caused by loss-of-function and gain-
of-function (GOF) variants in the corresponding genes, respectively, underlies a broad …

Cantú Syndrome (CS) is an autosomal dominant disorder caused by gain-of-function (GoF)
mutations in the Kir6. 1 and SUR2 subunits of KATP channels. KATP overactivity results in a …

Cantù syndrome (CS) arises from mutations in ABCC9 and KCNJ8 genes that lead to gain of
function (GOF) of ATP-sensitive potassium (KATP) channels containing SUR2A and Kir6. 1 …

Background Cardiomegaly caused by left ventricular hypertrophy is a risk factor for
development of congestive heart failure, classically associated with decreased systolic …