[HTML][HTML] Current mechanistic concepts in ischemia and reperfusion injury

MY Wu, GT Yiang, WT Liao, APY Tsai… - Cellular Physiology and …, 2018 - karger.com
Ischemia-reperfusion injury is associated with serious clinical manifestations, including
myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal …

Role of cardiolipin in mitochondrial function and dynamics in health and disease: molecular and pharmacological aspects

G Paradies, V Paradies, FM Ruggiero, G Petrosillo - Cells, 2019 - mdpi.com
In eukaryotic cells, mitochondria are involved in a large array of metabolic and bioenergetic
processes that are vital for cell survival. Phospholipids are the main building blocks of …

[HTML][HTML] Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia–reperfusion injury

J Wang, H Zhou - Acta Pharmaceutica Sinica B, 2020 - Elsevier
Mitochondrial damage is a critical contributor to cardiac ischemia/reperfusion (I/R) injury.
Mitochondrial quality control (MQC) mechanisms, a series of adaptive responses that …

Melatonin attenuates myocardial ischemia‐reperfusion injury via improving mitochondrial fusion/mitophagy and activating the AMPK‐OPA1 signaling pathways

Y Zhang, Y Wang, J Xu, F Tian, S Hu… - Journal of pineal …, 2019 - Wiley Online Library
Abstract Optic atrophy 1 (OPA1)‐related mitochondrial fusion and mitophagy are vital to
sustain mitochondrial homeostasis under stress conditions. However, no study has …

Mitophagy, mitochondrial dynamics, and homeostasis in cardiovascular aging

NN Wu, Y Zhang, J Ren - Oxidative Medicine and Cellular …, 2019 - Wiley Online Library
Biological aging is an inevitable and independent risk factor for a wide array of chronic
diseases including cardiovascular and metabolic diseases. Ample evidence has established …

Emerging role of mitophagy in cardiovascular physiology and pathology

PE Morales, C Arias-Durán, Y Ávalos-Guajardo… - Molecular aspects of …, 2020 - Elsevier
Healthy mitochondrial function is imperative for most tissues, but especially those with a high
energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular …

Mitochondrial fission protein 1: emerging roles in organellar form and function in health and disease

UK Ihenacho, KA Meacham, MC Harwig… - Frontiers in …, 2021 - frontiersin.org
Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for
mitochondrial division or fission and subsequently determined to mediate human …

MCU Up‐regulation contributes to myocardial ischemia‐reperfusion Injury through calpain/OPA‐1–mediated mitochondrial fusion/mitophagy Inhibition

L Guan, Z Che, X Meng, Y Yu, M Li, Z Yu… - Journal of cellular …, 2019 - Wiley Online Library
Mitochondrial dynamic disorder is involved in myocardial ischemia/reperfusion (I/R) injury.
To explore the effect of mitochondrial calcium uniporter (MCU) on mitochondrial dynamic …

ALDH2 attenuates ischemia and reperfusion injury through regulation of mitochondrial fusion and fission by PI3K/AKT/mTOR pathway in diabetic cardiomyopathy

X Tan, Y Chen, S Zou, W Wang, N Zhang… - Free Radical Biology …, 2023 - Elsevier
The function of mitochondrial fusion and fission is one of the important factors causing
ischemia-reperfusion (I/R) injury in diabetic myocardium. Aldehyde dehydrogenase 2 …

Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases

YE Li, JR Sowers, C Hetz, J Ren - Cell death & disease, 2022 - nature.com
The endoplasmic reticulum (ER) and mitochondria are interconnected intracellular
organelles with vital roles in the regulation of cell signaling and function. While the ER …