Dementia is a leading cause of disability and death worldwide. At present there is no
disease modifying treatment for any of the most common types of dementia such as …

Aging biomarkers are a combination of biological parameters to (i) assess age-related
changes,(ii) track the physiological aging process, and (iii) predict the transition into a …

Several molecular mechanisms have been described in Alzheimer's disease (AD), including
repressed gene transcription and mitochondrial and endoplasmic reticulum (ER) …

The dynamic changes in chromatin conformation alter the organization and structure of the
genome and further regulate gene transcription. Basically, the chromatin structure is …

Alzheimer's disease is a devastating neurodegenerative disorder that poses a significant
societal burden. Approval of anti-amyloid antibody therapies is a significant milestone for …

Abstract Background Prostate cancer (PCa) is the most common malignancy diagnosed in
men. Immune checkpoint blockade (ICB) alone showed disappointing results in PCa. It is …

Alzheimer's disease (AD) is an age-associated neurodegenerative disease. As the
population ages, the increasing prevalence of AD threatens massive healthcare costs in the …

Fear-, anxiety-and stress-related disorders are among the most frequent mental disorders.
Given substantial rates of insufficient treatment response and often a chronic course, a better …

Epigenetics modification is a process that does not change the sequence of
deoxyribonucleic acid (DNA) in disease progression but can alter the genetic expression of …

Aging is a ubiquitous biological process that is accompanied by a progressive functional
decline of various tissues and organs. This deterioration is the major risk for multiple chronic …