BRAF inhibitors in thyroid cancer: clinical impact, mechanisms of resistance and future perspectives

F Crispo, T Notarangelo, M Pietrafesa, G Lettini… - Cancers, 2019 - mdpi.com
The Kirsten rat sarcoma viral oncogene homolog (RAS)/v-raf-1 murine leukemia viral
oncogene homolog 1 (RAF)/mitogen-activated protein kinase 1 (MAPK) signaling cascade is …

[HTML][HTML] Predictive factors for central lymph node metastasis in patients with cN0 papillary thyroid carcinoma: a systematic review and meta-analysis

B Ma, Y Wang, S Yang, Q Ji - International journal of surgery, 2016 - Elsevier
Background and objectives Recently, some single-institution studies have reported risk
factors of CLNM in cN0 PTC patients, but results from those studies are not consistent. The …

Prophylactic central compartment lymph node dissection in papillary thyroid carcinoma: clinical implications derived from the first prospective randomized controlled …

D Viola, G Materazzi, L Valerio… - The Journal of …, 2015 - academic.oup.com
Background: The benefits of prophylactic central compartment lymph node dissection
(pCCND) in papillary thyroid cancer (PTC) are still under investigation. This treatment seems …

Acquired Secondary RAS Mutation in BRAFV600E-Mutated Thyroid Cancer Patients Treated with BRAF Inhibitors

ME Cabanillas, R Dadu, P Iyer, KB Wanland… - Thyroid, 2020 - liebertpub.com
Background: The BRAFV600E mutation is the most common driver mutation in papillary
thyroid cancer (PTC) and anaplastic thyroid cancer (ATC). This mutation is considered …

Associations between BRAFV600E and prognostic factors and poor outcomes in papillary thyroid carcinoma: a meta-analysis

C Liu, T Chen, Z Liu - World journal of surgical oncology, 2016 - Springer
Background The objective of this study is to perform a meta-analysis to evaluate the
associations between the BRAF V600E mutation status and aggressive clinicopathological …

Meta-Analyses of Association Between BRAFV600E Mutation and Clinicopathological Features of Papillary Thyroid Carcinoma

Q Zhang, S Liu, Q Zhang, Y Guan, Q Chen… - Cellular Physiology and …, 2016 - karger.com
Abstract Background/Aims: The function of BRAF V600E as a prognostic biomarker
continues controversial by reason of conflicting results in the published articles. Methods: A …

A shift in molecular drivers of papillary thyroid carcinoma following the 2017 World health organization classification: characterization of 554 consecutive tumors with …

JF Hang, JY Chen, PC Kuo, HF Lai, TL Lee, SK Tai… - Modern Pathology, 2023 - Elsevier
Most studies for comprehensive molecular profiling of papillary thyroid carcinoma (PTC)
have been performed before the 2017 World Health Organization (WHO) classification, in …

MicroRNA expression and association with clinicopathologic features in papillary thyroid cancer: a systematic review

P Aragon Han, CH Weng, HT Khawaja, N Nagarajan… - Thyroid, 2015 - liebertpub.com
Background: Studies have suggested that microRNAs (miR) may be useful prognostic
markers and are associated with aggressive clinicopathologic features in papillary thyroid …

Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four …

P Aragon Han, H Kim, S Cho, R Fazeli, A Najafian… - Thyroid, 2016 - liebertpub.com
Background: Studies have demonstrated an association of the BRAFV600E mutation and
microRNA (miR) expression with aggressive clinicopathologic features in papillary thyroid …

Prediction of cervical lymph node metastasis with contrast-enhanced ultrasound and association between presence of BRAFV600E and extrathyroidal extension in …

J Zhan, L Zhang, Q Yu, C Li, Y Chen… - … in medical oncology, 2020 - journals.sagepub.com
Objective: This study aimed to evaluate the correlation between cervical lymph node
metastasis (CLNM) and each of the ultrasound features, immunohistochemical factors, and …