BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …

Dextro-transposition of the great arteries (D-TGA) is the second most common cyanotic heart
disease, accounting for 5–7% of all congenital heart defects (CHDs). It is characterized by …

Background & Aims Biliary atresia (BA) is poorly understood and leads to liver
transplantation (LT), with the requirement for and associated risks of lifelong …

Congenital heart diseases (CHDs) are structural or functional defects present at birth due to
improper heart development. Current therapeutic approaches to treating severe CHDs are …

Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary
artery disease (CAD). However, non-European populations are underrepresented in …

Emerging evidence implicates common genetic variation-aggregated into polygenic scores
(PGS)-in the onset and phenotypic presentation of rare diseases. Here, we comprehensively …

Background Fetal diagnosis of congenitally corrected transposition of the great arteries
(ccTGA) has been increasingly reported; however, predictors of clinical outcomes remain …

Background Clinical factors are used to estimate late complication risk in adults after atrial
switch operation (AtrSO) for transposition of the great arteries (TGA), but heterogeneity in …

Congenital heart disease (CHD) is a rare structural defect that occurs in∼ 1% of live births.
Studies on CHD genetic architecture have identified pathogenic single-gene mutations in …

Congenital heart diseases (CHDs) represent a heterogeneous group of congenital defects,
with high prevalence worldwide. Non-invasive imaging is essential to guide medical and …